【摘要】 目的 分析前庭性偏头痛（vestibular migraine, VM）患者大脑皮质厚度改变区域，为VM发病机制的研究提供理论依据。方法 选择2021年6月—2022年12月于我院神经内科就诊的VM患者27例（设为VM组）,同期招募28例健康志愿者作为对照组。所有受试者进行全脑磁共振（MR）扫描，采用基于表面形态学分析（SBM）方法分析并比较两组受试者MR图像中大脑皮质厚度；对VM组患者皮质厚度异常脑区与其病程、头痛发作频率、头晕发作频率、头痛视觉模拟评分（VAS）分值等参数进行Spearman相关性分析。结果 与对照组相比，VM组患者左侧顶下小叶皮质厚度明显下降(P_vertex<0.01,P_cluster<0.05),但左侧顶下小叶皮质厚度与VM病程、头痛发作频率、头晕发作频率、头痛VAS分值均无相关性（P>0.05）。结论 前庭性偏头痛患者大脑皮质厚度异常区域位于左侧顶下小叶，左侧顶下小叶可能参与了VM发生的病理生理过程。更多还原

【Abstract】 Objective To investigate cortical thickness changes in patients with vestibular migraine（VM）, and to provide a basis for studying the pathogenesis of VM. Methods From June 2021 to December 2022, we enrolled 27 patients with VM visiting the department of neurology of our hospital and 28 healthy volunteers as control group. All the subjects underwent whole-brain magnetic resonance（MR） scanning. Using surface-based morphometry, the thickness of the cortex was analyzed on MR images and compared between the two groups. In the VM group, Spearman correlation analysis was performed to detect the correlation between cortical thickness changes and VM course, headache attack frequency, dizziness attack frequency, and headache intensity on the Visual Analogue Scale（VAS）. Results Compared with the control group, patients with VM had a significant decrease in the cortical thickness of the left inferior parietal lobule(P_vertex<0.01, P_cluster<0.05). However, there was no significant correlation between the cortical thickness of the left inferior parietal lobule and the course of VM, headache attack frequency, dizziness attack frequency, or VAS score（P>0.05）. Conclusion The cortical thickness of the left inferior parietal lobule is altered in patients with VM. The left inferior parietal lobule may be involved in the pathophysiological process of VM.更多还原