【摘要】 从化学成分、药理作用及肝毒性3个方面综述何首乌的研究进展。何首乌含有二苯乙烯苷类、蒽醌类、磷脂类、黄酮类等多种化学成分，具有延缓衰老、抗癌、抗疲劳、抗炎镇痛、保护心血管等药理作用。目前，何首乌引起肝毒性的化学成分探讨主要集中于3类，即蒽醌类、二苯乙烯苷类及鞣质类。加大何首乌肝毒性成分、肝毒性机制研究的力度，加强中药安全用药知识宣教，规范其炮制及使用，可以在一定程度上降低何首乌肝毒性。更多还原

【Abstract】 This review summarizes the advancement in the study of Polygoni Multiflori Radix(Heshouwu) from three perspectives: chemical constituents, pharmacological effects, and potential hepatotoxicity. Polygoni Multiflori Radix contains a variety of chemical compounds including stilbene glycosides, anthraquinones, phospholipids, and flavonoids. It demonstrates a spectrum of pharmacological properties, notably anti-aging, anti-cancer, anti-fatigue, anti-inflammatory analgesic effects, and cardiovascular protection. Current research on the hepatotoxicity of Polygoni Multiflori Radix mainly focuses on three categories of its chemical constituents: anthraquinones, stilbene glycosides, and tannins. Intensifying research into the hepatotoxic constituents and their underlying mechanisms of Polygoni Multiflori Radix, increasing awareness of safe usage of traditional Chinese herbal medicines, and standardizing its processing and application may help mitigate its hepatotoxic effects to some extent.更多还原