【摘要】 目的：评估针刺联合息风化痰通络颗粒对急性脑梗死（ACI）后溶栓患者的疗效，探讨其作用机制。方法：纳入ACI溶栓患者178例，按随机数字表法分为观察组和对照组各89例，最终164例完成研究，观察组81例，对照组83例。对照组接受常规治疗，观察组在对照组的基础上加用针刺联合息风化痰通络颗粒治疗，两组均治疗2周。评估比较两组的临床疗效、美国国立卫生研究院卒中量表（NIHSS）评分、日常生活活动能力量表（ADL）评分、血清炎症因子水平、氧化应激因子水平以及脑血流动力学。结果：治疗后，两组ADL评分、白细胞介素-10(IL-10)、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、过氧化氢酶（CAT）水平均较治疗前升高（P<0.05）,NIHSS评分、白细胞介素-1β(IL-1β)、超敏C反应蛋白（hs-CRP）、丙二醛（MDA）水平较治疗前降低（P<0.05），观察组NIHSS评分、IL-1β、IL-10、hs-CRP、MDA水平低于对照组（P<0.05）,ADL评分、SOD、GSH-Px、CAT水平高于对照组（P<0.05）。两组脑血流动力学指标均较治疗前改善，且观察组改善情况优于对照组（P<0.05）。观察组治疗总有效率95.06%，对照组84.34%，两组疗效比较，差异有统计学意义（P<0.05）。结论：针刺联合息风化痰通络颗粒能够促进ACI溶栓患者脑血流动力学恢复，改善缺血再灌注损伤的神经功能，其作用机制可能与减轻炎症反应、抑制氧化应激反应有关。更多还原

【Abstract】 Objective:To evaluate the therapeutic effect of acupuncture combined with Xifeng Huatan Tongluo Granule（息风化痰通络颗粒） on thrombolytic patients with acute cerebral infarction(ACI),and to explore the mechanism of action. Methods:After thrombolysis,178 patients with ACI were included and divided into the observation group and the control group according to random number table method,with 89 patients in each group. Finally,164 patients completed the study,with 81 in the observation group and 83 in the control group. The control group received conventional treatment,and the observation group was treated with acupuncture combined with Xifeng Huatan Tongluo Granule on the basis of the treatment of the control group. Both groups were treated for 2 weeks. The clinical efficacy,National Institutes of Health Stroke Scale(NIHSS) score,Activities of Daily Living Scale(ADL) score,serum levels of inflammatory factors,oxidative stress factors and cerebral hemodynamics were evaluated and compared between the two groups. Results:After treatment,the levels of ADL score,interleukin-10(IL-10),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) and catalase(CAT) in both groups were higher than those before treatment(P<0.05). The levels of NIHSS score,interleukin-1β(IL-1β),hypersensitive C-reactive protein(hs-CRP) and malondialdehyde(MDA) were lower than those before treatment(P<0.05),and the levels of NIHSS score,IL-1β,IL-10,hs-CRP and MDA in the observation group were lower than those in the control group(P<0.05). ADL score,SOD,GSH-Px and CAT levels in the observation group were higher than those in the control group(P<0.05). The indexes of cerebral hemodynamics in both groups were improved compared with those before treatment,and the improvement in the observation group was better than that in the control group(P<0.05). The total effective rate was 95.06% in the observation group and 84.34% in the control group. The difference of therapeutic effect between the two groups was statistically significant(P<0.05). Conclusion:Acupuncture combined with Xifeng Huatan Tongluo Granule can promote cerebral hemodynamic recovery and improve the nerve functional disorder caused by ischemia-reperfusion,and its mechanism may be related to reducing inflammation and inhibiting oxidative stress.更多还原