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基于图神经网络的神经精神疾病研究进展

Research progress in neuropsychiatric diseases based on graph neural network

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【作者】 王海源吴凯陈小怡彭润霖梁丽琴周静

【Author】 WANG Haiyuan;WU Kai;CHEN Xiaoyi;PENG Runlin;LIANG Liqin;ZHOU Jing;School of Biomedical Sciences and Engineering, South China University of Technology;National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology;Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders;Guangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia;Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology;School of Material Science and Engineering, South China University of Technology;

【通讯作者】 周静;

【机构】 华南理工大学生物医学科学与工程学院华南理工大学国家人体组织功能重建工程技术研究中心广东省精神疾病转化医学工程技术研究中心广东省老年痴呆诊断与康复工程技术研究中心华南理工大学广东省生物医学工程重点实验室华南理工大学材料科学与工程学院

【摘要】 神经精神疾病严重影响患者脑解剖结构、神经系统功能及心理健康,其早期识别与诊断对患者的治疗及康复具有重要意义。基于神经影像数据构建复杂的脑网络,可用于定量化分析神经精神疾病患者的脑结构及功能异常,为研究神经精神疾病的神经影像生物标记物提供重要参考。近年来,图神经网络具有处理非欧几里得数据、能充分利用节点与连边的拓扑结构和属性等优势,被广泛应用于神经精神疾病的辅助诊断研究。本文对图卷积神经网络的基本原理和神经精神疾病的最新研究进展进行了总结和分析,并展望了动态脑网络、大样本与多中心、可视化与可解释性等研究热点。

【Abstract】 Neuropsychiatric diseases seriously affect the anatomical structure of the brain, nervous system function, and mental health of patients. Early identification and diagnosis are of great significance for the treatment and rehabilitation of patients with neuropsychiatric diseases. The construction of complex brain networks based on neuroimage data can be used to quantitatively analyze the brain structure and function abnormalities in patients with neuropsychiatric diseases, and provide an important reference for the development of neuroimaging biomarkers for neuropsychiatric diseases. In recent years, graph neural network has been widely used in the diagnosis of neuropsychiatric diseases because of their advantages of processing non-Euclidean data and making full use of the topological structure and attributes of nodes and connected edges. We summarize the basic principles of graph convolutional network and the latest research progress in neuropsychiatric diseases, and look forward to research hotspots such as dynamic brain network, large sample and multi center, visualization and interpretability.

【基金】 广东省科技重点领域研发计划项目(2020B0404010002);国家重点研发计划(2023YFC2414500,2023YFC2414504);国家自然科学基金资助项目(72174082);广东省基础与应用基础研究基金杰出青年项目(2021B1515020064);广东省基础与应用基础研究基金(2022A1515140142);广东省教育厅重点实验室项目(2020KSYS001);广州市科技计划项目(202103000032,202206060005,202206080005,202206010077,202206010034)
  • 【文献出处】 生物医学工程研究 ,Journal of Biomedical Engineering Research , 编辑部邮箱 ,2024年03期
  • 【分类号】R741;R749;TP183
  • 【下载频次】20
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