【摘要】 三氧化二砷（As₂O₃）最初因治疗急性早幼粒细胞白血病（APL）而被研究者关注，而后被广泛应用于治疗多种恶性肿瘤。As₂O₃抗肿瘤作用机制主要包括：诱导肿瘤细胞凋亡和细胞周期阻滞、抑制血管生成、靶向作用于肿瘤干细胞以及逆转肿瘤细胞的化疗耐药性等。本文结合最新研究成果对As₂O₃抗肿瘤的分子机制进行了综述，以期为其抗肿瘤活性的深入研究和临床应用提供思路。更多还原

【Abstract】 Arsenic trioxide（As₂O₃） was initially concerned by researchers for the treatment of acute promyelocytic leukemia（APL）, and has since been widely used in the treatment of a variety of malignant tumors. The anti-tumor mechanism of As₂O₃ mainly includes: inducing apoptosis and cell cycle arrest of tumor cells, inhibiting angiogenesis,targeting cancer stem cells and reversing chemotherapy resistance of tumor cells. Based on the latest research results,the anti-tumor molecular mechanism of As₂O₃ is reviewed in this paper, which aims to provide ideas for further research and clinical application of its anti-tumor activity.更多还原