【摘要】 目的 研究4种不同药用部位药食同源中药材中多环芳烃的污染现状、溯源解析与健康风险。方法 采用固相分散萃取前处理技术联合高效液相色谱-紫外荧光串联检测器（HPLC-UV-FLD）同时在线检测技术，对中药材中4种不同药用部位进行污染检测、来源解析和健康风险评估。结果 中药材中16种多环芳烃（PAHs）污染水平范围在ND～150.50μg/kg，芘（Pyr）的检出率最高（51.43%），其次为?（Chr,45.71%），苯并[a]芘在所有样品中均未检出。2～6环中，4环占比最高（41.22%～50.95%），其次为3环（22.23%～49.05%）和2环（ND～36.56%）,5～6环均未检出。特征比率分析表明，石油、煤炭和生物质燃烧是药食同源中药材多环芳烃的主要来源。荧蒽（Flu）的致癌毒性贡献率最高（37.06%），其次为苯并[a]蒽（BaA,23.59%）。药食同源中药材终生致癌风险范围在2.90×10^-8～1.75×10^-7,ILCR值小于10^-6。结论 35种药食同源中药材中4种不同药用部位普遍存在PAHs污染，但其致癌风险可以忽略。更多还原

【Abstract】 Objective To investigate the pollution status,traceability analysis and health risk of polycyclic aromatic hydrocarbons （PAHs） in four different medicinal parts of traditional Chinese medicines （TCMs）.Methods The contamination detection,source analysis and health risk assessment of four different medicinal parts of TCMs were conducted by solid phase dispersion extraction pretreatment technology combined with HPLC-UV-FLD on-line detection technology.Results The pollution levels of 16 PAHs in different medicinal parts of TCMs were among ND-150.50μg/kg,pyrene （Pyr） had the highest detection rate （51.43%） followed by chrysene （Chr,45.71%）,and benzo（a）pyrene was not detected in all samples.Among 2-6 rings,4 rings accounted for the highest proportion（41.22%-50.95%）,followed by 3 rings （22.23%-49.05%） and 2 rings （ND-36.56%）,and 5-6 rings were not detected.Characteristic ratio analysis showed that petroleum,coal and biomass combustion were the main sources of PAHs.Fluoranthrene （Flu） contributed the most to carcinogenic toxicity （37.06%）,followed by benzo （a） anthracene （BaA,23.59%）.The lifetime carcinogenic risk range of TCMs was 2.90×10^-8-1.75×10^-7,and ILCR value was less than 10^-6.Conclusion PAHs contamination is common in four different medicinal parts of 35 TCMs which are used also as food,but its carcinogenic risk can be ignored.更多还原