【摘要】 [目的]建立了QuEChERS法结合高效液相色谱-串联质谱（HPLC-MS/MS）测定高粱中苯嘧磺草胺残留的检测方法。[方法]高粱植株和籽粒经乙腈-水提取，土壤经乙腈-0.2%甲酸水提取，经PSA、C₁₈、GCB和无水MgSO₄净化，采用HPLC-MS/MS测定，外标法定量。[结果]在0.001～0.5 mg/L范围内，苯嘧磺草胺质量浓度与其响应值线性关系良好。添加的质量分数为0.01、0.1、0.5 mg/kg时，苯嘧磺草胺在高粱植株、土壤和籽粒中的平均回收率在85.6%～101.7%之间，相对标准偏差（RSDs）在1.48%～6.28%之间，定量限（LOQ）均为0.01 mg/kg。结果表明，苯嘧磺草胺在内蒙古和吉林2个试验点土壤中的消解动态符合一级反应动力学方程，半衰期分别为3.5、3.7 d；苯嘧磺草胺在高粱植株、土壤和籽粒基质中的最终残留均低于定量限。[结论]70%苯嘧磺草胺水分散粒剂按照推荐剂量施用收获期安全。试验可以为苯嘧磺草胺的安全使用和最大残留限量（MRL）的制定提供参考依据。更多还原

【Abstract】 [Aims] A QuEChERS method combined with HPLC-MS/MS was developed for the determination of saflufenacil residues in sorghum. [Methods] Sorghum plants and grains were extracted with acetonitrile and water,and soil was extracted with acetonitrile and 0.2% formic acid water. The extracts were purified by PSA, C₁₈, GCB and anhydrous MgSO₄, determined by HPLC-MS/MS, and quantified by external standard method. [Results] In the range of 0.001-0.5 mg/L, the mass concentration of saflufenacil had a good linear relationship with its response value.At the spiked levels of 0.01, 0.1 and 0.5 mg/kg, the average recoveries of saflufenacil in sorghum plant, soil and grain ranged from 85.6%-101.7% with relative standard deviations（RSDs） of 1.48%-6.28%, and the limit of quantitation（LOQ） was 0.01 mg/kg. The results showed that the dissipation dynamics of saflufenacil in the soil of Inner Mongolia and Jilin were in accordance with the first-order reaction kinetic equation and the half-lives were 3.5 and 3.7 d,respectively. The final residues of saflufenacil in sorghum plant, soil and grain matrix were lower than the limit of quantitation. [Conclusions] It is safe to apply saflufenacil 70% water dispersible granules at the recommended dose during the harvest period. This study can provide a reference for the safe use of saflufenacil and the formulation of maximum residue limit（MRL）.更多还原