【摘要】 脓毒症(Sepsis)是指宿主对感染的反应失调而导致危及生命的器官功能障碍，病死率高。脓毒症导致多脏器功能障碍，其中肝脏较容易受到损伤，且损伤机制复杂，涉及微循环障碍、肠道菌群失调、炎症反应及细胞自噬等。目前临床上对脓毒症诱导的肝损伤（sepsis-induced liver injury,SILI）尚无有效的治疗办法，只能对症治疗，但随着对其机制的深入研究，一些新的治疗方法如免疫治疗、中药治疗等被用于脓毒症的治疗当中。本文对SILI的发病机制和治疗进展进行了综述，希望为脓毒症肝损伤的治疗提供帮助。更多还原

【Abstract】 Sepsis is defined as a life-threatening organ dysfunction with a dysregulated host response to infection and a high mortality rate. Sepsis leads to multiple organ dysfunction, in which the liver is more prone to damage, and the damage mechanism is complex, involving microcirculation disorder, intestinal flora disorder, inflammatory response and cell autophagy.At present, there is no effective treatment for sepsis-induced liver injury(sepsis-induced liver injury, SILI), which can only be symptomatic. However, with the in-depth study of its mechanism, some new treatment methods such as immunotherapy and traditional Chinese medicine treatment are used in the treatment of sepsis. This review of the pathogenesis and therapeutic progress of SILI, hopes to facilitate the treatment of septic liver injury.更多还原