【摘要】 为更好地治疗骨缺损患者，提高骨修复材料性能，将丝素蛋白改性材料（SFMM）、壳聚糖（CS）、矿化胶原（MC）复合，制备一种新型的复合骨康复材料，并对其性能和应用效果进行研究。结果表明，随着SFMM掺量百分比的增多，SFMM/CS复合材料压缩弹性模量增大，降解率下降。其中，5%SFMM比1%SFMM复合材料压缩弹性模量提高64.7%、降解率降低42.2%。同时提高SFMM掺量，会降低复合材料溶胀性能，促进细胞增殖；添加矿化胶原（MC）可降低复合材料降解率，增强材料细胞相容性；在临床应用中，SFMM/CS/MC复合材料的应用效果较好。SFMM/CS/MC复合材料具备良好的综合性能，可以用于治疗骨缺损患者。更多还原

【Abstract】 In order to better treat patients with bone defects and improve the performance of bone repair materials,a new type of composite bone rehabilitation materials was prepared by combining silk fibroin modified materials(SFMM),chitosan(CS)and mineralized collagen(MC),and its properties and application effects were studied.The results showed that with the increase of SFMM content,the compressive elastic modulus of SFMM/CS composite material increased and the degradation rate decreased. Among them,the compressive modulus of 5wt% SFMM composite material increased by 64.7% and the degradation rate decreased by 42.2% compared to 1wt% SFMM composite material. At the same time,increasing the SFMM content reduced the swelling performance of the composite material and promoted cell proliferation. Adding mineralized collagen(MC)could reduce the degradation rate of composite materials and enhance their cellular compatibility. In clinical applications,the application effect of SFMM/CS/MC composite materials was good. SFMM/CS/MC composite materials have good comprehensive properties and can be used to treat patients with bone defects.更多还原