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Biomaterial design for regenerating aged bone:materiobiological advances and paradigmatic shifts

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【作者】 戴凯； 耿振； 张文超； 魏雪； 王靖； 聂广军； 刘昌胜；

【Author】 Kai Dai;Zhen Geng;Wenchao Zhang;Xue Wei;Jing Wang;Guangjun Nie;Changsheng Liu;Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology;State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology;Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology;Key Laboratory for Ultrafine Materials of the Ministry of Education, East China University of Science and Technology;Institute of Translational Medicine,Shanghai University;National Center for Translational Medicine(Shanghai) SHU Branch,Shanghai University;CAS Key Laboratory for Biomedical Effects of Nanomaterials &Nanosafety, CAS Centre for Excellence in Nanoscience, National Centre for Nanoscience and Technology;Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences;

【通讯作者】 王靖;聂广军;刘昌胜;

【机构】 Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology； State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology； Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology； Key Laboratory for Ultrafine Materials of the Ministry of Education, East China University of Science and Technology； Institute of Translational Medicine,Shanghai University； National Center for Translational Medicine(Shanghai) SHU Branch,Shanghai University； CAS Key Laboratory for Biomedical Effects of Nanomaterials &Nanosafety, CAS Centre for Excellence in Nanoscience, National Centre for Nanoscience and Technology； Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences；

【摘要】 China’s aging demographic poses a challenge for treating prevalent bone diseases impacting life quality. As bone regeneration capacity diminishes with age due to cellular dysfunction and inflammation, advanced biomaterials-based approaches offer hope for aged bone regeneration. This review synthesizes materiobiology principles, focusing on biomaterials that target specific biological functions to restore tissue integrity. It covers strategies for stem cell manipulation, regulation of the inflammatory microenvironment,blood vessel regeneration, intervention in bone anabolism and catabolism, and nerve regulation. The review also explores molecular and cellular mechanisms underlying aged bone regeneration and proposes a database-driven design process for future biomaterial development. These insights may also guide therapies for other age-related conditions, contributing to the pursuit of ‘healthy aging’.

【Abstract】 China’s aging demographic poses a challenge for treating prevalent bone diseases impacting life quality. As bone regeneration capacity diminishes with age due to cellular dysfunction and inflammation, advanced biomaterials-based approaches offer hope for aged bone regeneration. This review synthesizes materiobiology principles, focusing on biomaterials that target specific biological functions to restore tissue integrity. It covers strategies for stem cell manipulation, regulation of the inflammatory microenvironment,blood vessel regeneration, intervention in bone anabolism and catabolism, and nerve regulation. The review also explores molecular and cellular mechanisms underlying aged bone regeneration and proposes a database-driven design process for future biomaterial development. These insights may also guide therapies for other age-related conditions, contributing to the pursuit of ‘healthy aging’.

【关键词】 materiobiology； biomaterial design； aging； bone regeneration； artificial intelligence；
【Key words】 materiobiology； biomaterial design； aging； bone regeneration； artificial intelligence；
【基金】 supported by the Basic Science Center Program(T2288102);the Key Program of the National Natural Science Foundation of China (32230059);the National Natural Science Foundation of China (32301123);the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry(JKVD1211002);the Wego Project of Chinese Academy of Sciences ((2020) 005);the China Postdoctoral Science Foundation (2022M721147)
  • 【文献出处】 National Science Review ,国家科学评论(英文版) , 编辑部邮箱 ,2024年05期
  • 【分类号】TB30;R318.08
  • 【下载频次】3
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