【摘要】 目的：探讨亚剂量多西环素联合复合酸治疗中重度痤疮的疗效及安全性。方法：于2021年3月-2022年11月，选取笔者医院皮肤科门诊确诊的中重度痤疮患者90例，按照随机数字表法分为A组与B组和C组，每组30例。A组患者给予亚剂量（40 mg/d）多西环素片联合复合酸治疗，B组患者给予常规剂量（100 mg/d）多西环素片联合复合酸治疗，C组给予患者常规剂量（100 mg/d）多西环素片，总疗程12周。比较各组的临床效果，痤疮严重程度及不良反应。结果：治疗后，A组、B组的总有效率明显高于C组（P<0.05）；治疗12周后，各组粉刺、丘疹、脓疱、囊肿、结节皮损均低于治疗前，临床症状评分及GAGS评分比较，结果显示A组、B组均低于C组（P<0.05),A组、B组比较差异无统计学意义（P>0.05);A组总不良反应发生率明显低于B组、C组（6.67%,83.33%,86.67%,P<0.05）,C组胃肠道不良反应发生率较高。结论：亚剂量多西环素联合复合酸治疗中重度痤疮的临床效果，与常规剂量多西环素联合复合酸的临床效果相当。但亚剂量多西环素不良反应发生率低，特别是胃肠道反应发生率更低，患者耐受度高，具有使用及推广价值。更多还原

【Abstract】 Objective To investigate the efficacy and safety of subantimicrobial-dose of doxycycline combined with compound acid in the treatment of moderate to severe acne. Methods From march 2021 to november 2022, a total of 90 patients with moderate to severe acne who was selected in the dermatology department of the author’s hospital, and they were divided into A、B、C groups,with 30 cases in each group. Group A was given subdose(40 mg/d) doxycycline tablets combined with compound acid treatment, group B was given conventional dose(100 mg/d) doxycycline tablets combined with compound acid treatment,group C was given conventional dose(100 mg/d) doxycycline tablets, a total course of treatment for 12 weeks. The clinical effect, severity of acne, and adverse reactions of each group were compared. Results After treatment, the total effective rate of group A and B was significantly higher than that of group C(P<0.05). After 12 weeks of treatment, pimples, papules, pustules,cysts and nodular lesions in all groups were lower than before treatment. The results of comparison of clinical symptom scores and GAGS severity showed that there were significant differences between group A and Group C(P<0.05), while there was no statistical significance between group A and group B(P>0.05). The incidence of adverse reactions in group A was significantly lower than that in groups B and C(6.67%, 83.33%, 86.67%, P<0.05).The group C had a higher incidence of gastrointestinal adverse events. Conclusion The clinical effect of Subantimicrobial-dose of Doxycycline Combined with compound acids in the treatment of moderate and to severe acne is similar to that of conventional dose doxycycline combined with compound acid,but the adverse reactions of subantimicrobial-dose of doxycycline are low, especially the incidence of gastrointestinal reactions is lower, the tolerance of patients is high, and it has the use and promotion value.更多还原