【摘要】 良性前列腺增生症(benign prostatic hyperplasia,BPH)是一种常见的男性疾病,其发病基础是老年和具有功能的睾丸,但是迄今为止,其发病机制尚未完全明了。上皮间质转化(epithelial-mesenchymal transition,EMT)直接参与恶性肿瘤发生发展,其涉及细胞从上皮细胞向间充质细胞的转化,伴随着细胞形态的改变、细胞间相互作用的调节以及细胞的迁移和侵袭。近年来研究提示EMT是前列腺增生的一个关键过程,在前列腺增生的发生发展中起到重要作用,可以通过影响细胞的增殖、存活、衰老、代谢和免疫等生理过程,进而影响前列腺组织的生长和重构。其中,研究发现调节EMT的磷脂酰肌醇3-激酶(phosphatidylinostol3-lcinases,PI3K)/蛋白激酶b信号通路(AKT)和转化生长因子β信号通路(transforming groweh factor-β,TGF-β)等,可以对前列腺增生的发生发展产生重要影响。因此,深入研究EMT在前列腺增生中的作用机制,有助于发掘新的治疗靶点,本综述旨在深入探讨EMT在前列腺增生发病机制中的关键作用,着重强调细胞信号通路在良性前列腺增生EMT的机制,为未来研究和治疗提供了有益的参考和洞察,为疾病的预防和治疗提供新的思路。更多还原

【Abstract】 Benign prostatic hyperplasia(benign prostatic hyperplasia,BPH) is a common male disease based on aging and normal functioning testis,but its pathogenesis has not been fully understood.Epithelial-mesenchymal transition(EMT) is directly involved in the development of malignant tumors.It involves the transformation of cells from epithelial cells to mesenchymal cells,accompanied by changes in cell morphology,regulation of cell-cell interactions,and cell migration and invasion.In recent years,studies have suggested that EMT is a key process in BPH,playing a crucial role in its occurrence and development.It can affect physiological processes such as cell proliferation,survival,aging,metabolism,and immunity,thereby influencing the growth and remodeling of prostatic tissue.Among these,studies have found that signaling pathways regulating EMT,such as PI3K/AKT and TGF-β,can have a significant impact on the occurrence and development of BPH.Therefore,in-depth research into the mechanisms of EMT in BPH can help uncover new therapeutic targets and provide new insights into the treatment of BPH.This review aims to delve into the crucial role of epithelial-mesenchymal transition in the pathogenesis of benign prostatic hyperplasia.It places particular emphasis on the cellular signaling pathways involved in EMT in benign prostatic hyperplasia,offering valuable insights and references for future research and treatment,thus paving the way for novel approaches to disease prevention and management.更多还原