【摘要】 荨麻疹的临床特征为皮肤反复发生的瘙痒性风团，可合并血管性水肿。肥大细胞脱颗粒，释放组胺及各种细胞因子和炎性介质，导致血管扩张、通透性增加、细胞募集及瘙痒发生，在荨麻疹发病机制中起着重要的作用。本文从肥大细胞外因素、细胞表面受体、细胞内信号通路等方面对肥大细胞脱颗粒的影响因素进行综述。更多还原

【Abstract】 Urticaria is a disease characterized by recurring itchy wheals and angioedema or both. Degranulation of mast cells plays an important role in the pathogenesis of urticaria, which increases the release of histamine, various cytokines and inflammatory mediators, and leads to the vasodilation, increased permeability, cell recruitment and pruritus.In this article, we review the influencing factors of skin mast cell degranulation from the extracellular substance, receptors on mast cell surface, and intracellular signal pathways.更多还原