【摘要】 目的：分析PD-L1(细胞程序性死亡-配体1)在肺腺癌患者恶性胸水脱落细胞中的表达，分析PD-L1与肺腺癌患者临床病理参数的关系。方法：采用免疫组化方法检测54例肺腺癌患者恶性胸水中的脱落细胞标本中PD-L1的表达，同时检测73例肺腺癌组织标本中PD-L1的表达，分析两者之间表达一致性。结果：在54例细胞标本中PD-L1阳性率68.5%，而73例组织标本中仅为53.4%(P>0.05)；其中31例肺腺癌患者既有恶性胸水细胞标本，也有组织标本，恶性胸水中肿瘤细胞PD-L1阳性比例TPS 1%-49%为26%,TPS≥50%为39%,PD-L1在同一患者的组织学和细胞学标本中的表达阳性率一致性尚可（Kappa=0.49,P<0.05）。恶性胸水细胞中PD-L1表达与淋巴结转移状态相关（P<0.05），而与患者性别、年龄、远处转移等均无相关性（P>0.05）。结论：在肺腺癌恶性胸水细胞学标本中检测PD-L1的结果可靠，在组织学标本无法获得的情况下，可用恶性胸水细胞学标本进行PD-L1检测。更多还原

【Abstract】 Objective:To evaluate the relationship between PD-L1 expression and clinicopathological in lung adenocarcinoma. Methods: 54 cases of malignant pleural effusion and 73 cases of lung adenocarcinoma were detected by immunohistochemical. Results: The positive rate of PD-L1 in malignant pleural fluid was 68.5% in cytological specimens and 53.4% in histological specimen(P>0.05). Among them,31patients had malignant pleural fluid cytological and histological specimens. The positive proportion of PD-L1 expression in malignant pleural fluid was 26% in TPS from 1% to 49%, and 39% in TPS≥50%. The expression of PD-L1 was moderately consistent between then(Kappa=0.49, P<0.05). PD-L1 expression was correlated with lymph node metastasis status(P<0.05) only. Conclusion: PD-L1 can be detected reliably in malignant pleural fluid cytological specimens of lung adenocarcinoma.更多还原