【摘要】 氯代多氟烷基醚磺酸（Cl-PFESA，商品名F-53B）是全氟辛烷磺酸（PFOS）的替代品，主要成分为6:2 Cl-PFESA和8:2 Cl-PFESA，是目前已知的最具生物持久性的全氟及多氟烷基物质（PFASs）。自1975年中国首次合成并将其用作电镀工业的抑雾剂，F-53B已经被使用了40多年。近几年随着对该物质的深入研究，许多基质和人体样本中均已检测到F-53B的存在，且在中国已成为流行病学研究中母体和脐带血清中浓度排名前三的PFAS。目前，有限的流行病学研究提示了F-53B对母婴健康具有多种不良的影响。因此，本文对F-53B的母婴暴露水平以及其对健康的不良影响进行综述，旨在为评估F-53B母婴毒性效应和确定安全限值提供一定的参考。更多还原

【Abstract】 Chlorinated polyfluoroalkyl ether sulfonic acid(Cl-PFESA, trade name F-53B), a substitute for perfluorooctane sulfonate(PFOS), notably featuring 6:2 Cl-PFESA and 8:2 Cl-PFESA as its primary components, are the most biologically persistent per-and polyfluoroalkyl substances(PFAS)currently known. Since its initial synthesis in China in 1975, F-53B has served as an antifogging agent in the electroplating industry for over four decades. Recently, F-53B has been detected across various matrix and human samples, ranking among the top three PFAS concentrations in maternal and umbilical cord blood sera in China, according to available epidemiological studies.Current limited epidemiological studies indicate that F-53B poses multiple adverse effects on maternal and infant health. Therefore, this article reviewed the exposure levels of F-53B in mothers and infants, along with its adverse health effects, thereby providing insights for evaluating the toxic effects of F-53B on maternal and infant health and establishing safety thresholds.更多还原