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环境新污染物影响胚胎发育的毒作用机制探索

Exploration of developmental toxicity mechanism of emerging environmental contaminants

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【作者】 陈涛张蕴晖

【Author】 CHEN Tao;ZHANG Yunhui;School of Public Health, Soochow University;School of Public Health/Key Laboratory of Public Health Safety, Ministry of Education, Fudan University;

【通讯作者】 张蕴晖;

【机构】 苏州大学公共卫生学院复旦大学公共卫生学院/公共卫生安全教育部重点实验室

【摘要】 环境新污染物的健康风险目前受到高度关注,越来越多的证据表明多种环境新污染物母体暴露干扰胚胎发育。由于毒作用机制尚不明确,这限制了对环境新污染物发育毒性的风险评估及防治。本专栏中多篇文章利用动物模型、大数据分析以及单细胞测序等技术手段,对多种环境新污染物干扰胚胎发育的分子机制进行研究并做出综述。希望此专栏能促进对环境新污染物发育毒性毒作用机制的探索,并为相关政策制定提供参考。

【Abstract】 The health risk posed by emerging environmental contaminants has become a public concern. Increasing evidence indicate that maternal exposure to multiple emerging environmental contaminants disrupts embryonic development. However, the underlying mechanisms of this developmental toxicity remain unclear, hindering risk assessment and prevention efforts. In this column, the developmental toxicity mechanisms of various emerging pollutants were studied by employing model animals, big data analysis, and single-cell sequencing. We hope that this column will encourage further research into the developmental toxicity mechanisms of emerging environmental contaminants and provide a scientific base for policy-making.

  • 【文献出处】 环境与职业医学 ,Journal of Environmental and Occupational Medicine , 编辑部邮箱 ,2024年12期
  • 【分类号】R114
  • 【下载频次】25
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