【摘要】 免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）作为治疗肿瘤的重要药物，显著延长恶性肿瘤患者生存期。同时，免疫相关不良反应也逐渐增多；其中，ICIs存在增加急性冠脉事件的发生风险，但目前临床报道少见。本文通过1例肺小细胞神经内分泌癌患者使用ICIs后出现急性心肌梗死的病史资料分析，提示临床医生应警惕ICIs相关急性心肌梗死的发生，通过早期识别、及早干预改善患者不良预后。更多还原

【Abstract】 As an important advance in the treatment of anti-tumor therapy, immune checkpoint inhibitors significantly prolong the survival of patients with malignant tumors. At the same time, immune-related adverse reactions are also increasing,among which ICIs have increased the risk of acute coronary events, but clinical reports are rare. This paper analyzes the history of a patient with pulmonary small cell neuroendocrine carcinoma who developed acute myocardial infarction after ICIs treatment,suggesting that clinicians should be alert to the occurrence of ICIs-related acute myocardial infarction, and improve the prognosis of patients through early identification and intervention.更多还原