【摘要】 [目的]比较利那洛肽方案、聚乙二醇电解质方案在结肠镜肠道准备中的效果，分析利那洛肽在肠道准备中的辅助应用价值。[方法]对拟行结肠镜检查的患者随机分为利那洛肽组(319例)和对照组(334例)进行肠道准备，利那洛肽组采用利那洛肽290μg+聚乙二醇电解质2 L方案，对照组采用聚乙二醇电解质3 L分2次服用法。收集患者基本信息、肠道准备中主观感受和不良反应、排便次数和末次大便性状等资料，结肠镜操作医生采用单盲原则对镜下各阶段肠道的清洁度和泡沫程度进行评分。应用SPSS23.0软件对2组各指标进行统计分析。[结果]利那洛肽组第2阶段排便次数显著多于对照组，2组的总排便次数比较差异无统计学意义。利那洛肽组升结肠、横结肠、降结肠的清洁度、及肠道清洁度总评分与对照组比较差异无统计学意义。利那洛肽组恶心、头晕、口干的发生率显著低于对照组。利那洛肽方案各阶段肠道清洁度均与末次大便清澈度呈正相关。[结论]利那洛肽可辅助用于肠道准备，可减少传统肠道准备药物的剂量、减少饮水量、减轻肠道准备不适症状，从而促进肠道准备的舒适化程度。更多还原

【Abstract】 [Objective]To analyze the application value of linaclotide in bowel preparation before colonoscopy.[Methods]Patients undergoing colonoscopy were randomly divided into two groups for bowel preparation: linaclotide group and control group.Linaclotide 290μg + 2 L polyethylene glycolelectrolyte were used for patients of linaclotide group, and 3 L polyethylene glycolelectrolyte were used for patients of control group.Patients’ information, subjective feelings and adverse reactions during bowel preparation, numbers of bowel movements, and last stool characteristics were collected.Cleanliness and foaminess of every segment of the intestine were scored by colonoscopy operators using the single-blind principle.The SPSS23.0 software was used for statistical analysis of the indicators in the two groups.[Results]There were 319 patients in linaclotide group and 334 patients in control group.There was no statistical difference in the total number of defecation between two groups, and the defecation numbers in linaclotide group was significantly higher than that of control group.There were no statistical difference in the cleanliness scores of ascending colon, transverse colon, descending colon, and the total cleanliness of all intestinal segment between two groups.The incidence of nausea, dizziness, and dry mouth was significantly lower in linaclotide group than that in control group.In the linaclotide group, the average daily stool frequency was negatively correlated with the cleanliness of the descending colon and rectum, while the cleanliness of each segment of the intestine was significantly correlated with the cleanliness of the last stool.[Conclusion]There is auxiliary application value of linaclotide in bowel preparation by reducing the dose of bowel preparation drugs, water consumption and the discomfort.Linaclotide can promote the comfort of bowel preparation.更多还原