【摘要】 脑卒中有很高的发病率、致残率、病死率。早期识别颈动脉粥样硬化斑块并进行干预可以预防脑卒中的发生。研究表明，动脉粥样硬化斑块与免疫介导的炎症反应密切相关，且靶向炎症治疗有望成为治疗动脉粥样硬化斑块的新手段。本文系统性回顾了不同细胞的免疫调控机制在动脉粥样硬化斑块炎症反应中的作用，以及潜在的靶向炎症治疗药物，以期为动脉粥样硬化相关疾病的临床治疗提供参考。更多还原

【Abstract】 Stroke has a high morbidity, disability and mortality. Early identification and intervention of carotid atherosclerotic plaque can prevent the occurrence of stroke. Studies have shown that atherosclerotic plaques are closely related to immune-mediated inflammation, and targeted inflammation therapy is expected to become a new method for the treatment of atherosclerotic plaques. This article systematically reviewed the role of immune regulatory mechanisms of different cells in the inflammatory response of atherosclerotic plaques, as well as potential targeted anti-inflammatory drugs, in order to provide reference for the clinical treatment of atherosclerosis related diseases.更多还原