【摘要】 糖尿病肾脏疾病是长期高血糖引起的肾脏结构功能异常损伤疾病。糖尿病肾脏疾病中足细胞损伤是肾脏炎症、肾小球过滤屏障损伤和肾脏纤维化变化的主要原因。泛素蛋白酶体系统是细胞内蛋白清除的主要途径，近年来研究发现其在糖尿病肾脏疾病足细胞损伤中发挥重要作用。高糖相关损伤因素引起足细胞蛋白酶体功能异常、泛素连接酶表达水平改变、去泛素酶活动增加，进而造成足细胞内损伤性蛋白积累或者保护性蛋白异常降解，促进足细胞损伤。现对糖尿病肾脏疾病中足细胞损伤和泛素蛋白酶体参与的损伤机制进行综述。更多还原

【Abstract】 Diabetic kidney disease(DKD) is a disease of abnormal renal structure and function due to long-term hyperglycemia. Podocyte injury is a major cause of renal inflammation, glomerular filtration barrier injury and renal fibrosis. Ubiquitin proteasome system is involved in intracellular protein clearance. Recent studies have confirmed that it plays an important role in podocyte injury of DKD. High glucose-related injury factors cause an abnormal function of podocyte proteasome, an altered expression level of ubiquitin ligase and an enhancement of deubiquitinating enzyme activity. As a result, an accumulation of injurious protein or an abnormal degradation of protective protein in podocyte may accentuate podocyte injury. This review focused upon the mechanisms of podocyte injury and ubiquitin proteasome involvement in DKD.更多还原