【摘要】 目的:探讨精神分裂症患者血清胰岛素样生长因子-1(IGF-1)和胰岛素样生长因子结合蛋白1(IGFBP-1)水平及与认知功能之间的关系。方法:采用酶联免疫吸附双抗体夹心法(ELISA)检测103例精神分裂症患者和64名正常对照的血清IGF-1和IGFBP-1蛋白的表达水平；采用阳性和阴性症状量表(PANSS)评估患者的临床症状及严重程度；使用中文版认知功能成套测验(MCCB)评价研究对象的认知功能。结果:精神分裂症组外周血中的IGFBP-1表达增高(P=0.01),而IGF-1的表达与HCs组无明显差异(P>0.05)。IGF-1的表达水平与患者认知功能维度中的工作记忆、言语学习与记忆、视觉学习与记忆、社会认知及MCCB总分均呈负相关(P均<0.05),IGFBP-1的表达水平与患者的认知功能维度中的处理速度评分呈负相关(P<0.05),正常对照组IGF-1和IGFBP-1与认知功能评分均无相关性(P>0.05)。结论:精神分裂症患者血清中IGF-1与IGFBP-1的表达与患者认知功能存在负相关，表明IGF-1及IGFBP-1在精神分裂症认知损伤中发挥了一定的作用。更多还原

【Abstract】 Objective: To investigate the relationship between the levels of serum insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-1(IGFBP-1) and cognitive function in patients with schizophrenia. Method:The expression levels of serum IGF-1 and IGFBP-1 proteins in 103 patients with schizophrenia and 64 healthy controls(HCs) were detected using enzyme-linked immunosorbent assay(ELISA).The clinical symptoms and severity of patients were evaluated using the Positive and Negative Syndrome Scale(PANSS).The cognitive function of the subjects was evaluated using the Chinese version of the Cognitive Function Battery(MCCB). Results:The expression of IGFBP-1 in peripheral blood of patients with schizophrenia increased(P=0.01),while the expression of IGF-1 showed no significant difference compared with the HCs group(P>0.05).The expression level of IGF-1 was negatively correlated with the working memory, verbal learning and memory, visual learning and memory, social cognition, and total score of MCCB in the cognitive function dimensions of patients(all P<0.05),while the expression level of IGFBP-1 was negatively correlated with the processing speed score in the cognitive function dimensions of patients(P<0.05).There was no correlation between the expression levels of IGF-1 and IGFBP-1 in the healthy controls and the cognitive function scores(P>0.05). Conclusion:The expression of IGF-1 and IGFBP-1 in the serum of patients with schizophrenia is negatively correlated with the cognitive function of patients, indicating that this IGF-1/IGFBP-1 plays a certain role in the cognitive impairment of schizophrenia.更多还原