【摘要】 慢性HBV感染是一种全球性公共卫生问题，是我国肝纤维化、肝硬化、肝衰竭及原发性肝癌的主要原因。随着人们生活水平的提高及饮食结构的改变，非酒精性脂肪性肝病（NAFLD）发病率也逐渐升高。基于人群的研究发现HBV感染可影响NAFLD的发生，其中机制仍不明确。肝脂肪变性也会影响HBV血清病原学标志物的表达，合并NAFLD或其他代谢功能障碍会增加HBV感染者肝纤维化、肝硬化及肝癌的风险。慢性HBV感染与代谢障碍密切相关，未来需要更多研究进一步阐明相关机制，为临床诊疗提供理论依据。更多还原

【Abstract】 Chronic hepatitis B virus(HBV) infection is a worldwide public health issue and a leading cause of liver fibrosis, liver cirrhosis, liver failure, and primary liver cancer in China. The incidence rate of nonalcoholic fatty liver disease(NAFLD) is gradually increasing with the improvement in the living standards of people and the changes in dietary structure. Population-based studies have found that HBV infection can influence the development of NAFLD, but the mechanism remains unknown. Hepatic steatosis can also influence the expression of HBV serum pathogenic indicators, and its combination with NAFLD and other metabolic dysfunction diseases can increase the risk of liver fibrosis, liver cirrhosis, and liver cancer. Chronic HBV infection is closely associated with metabolic dysfunction, and more studies are needed in the future to better understand related mechanisms, so as to provide a theoretical foundation for clinical diagnosis and treatment.更多还原