【摘要】 目的 探讨帕金森病(Parkinson’s disease,PD)患者血清尿酸(uric acid, UA)、同型半胱氨酸(homocysteine, HCY)、胱抑素C(cystatin C,CysC)水平与PD患者的运动症状及认知功能的关系。方法 选取2019年1月至2022年8月河北省人民医院收治PD患者200例。按照首发运动症状分为震颤(tremor-dominant, TD)组(n=104)和非震颤(non-tremor-dominant, NTD)组(n=96),依据蒙特利尔认知评估量表分为PD认知功能正常(cognitive normal in Parkinson’s disease,PD-CN)组(n=118)和PD认知功能障碍(cognitive impairment in Parkinson’s disease,PD-CI)组(n=82)。分别比较各组血清UA、HCY、CysC水平，采用多因素logistic回归分析PD患者TD和认知功能障碍的危险因素。结果 与NTD组相比，TD组血清UA水平较高，Hcy、Cys C水平较低，差异均有统计学意义(P<0.05);多因素logistic回归分析结果显示，UA、 HCY和Cys C是PD患者TD的独立危险因素。与PD-CI组相比，PD-CN组血清UA水平较高，HCY、Cys C水平较低，差异均有统计学意义(P<0.05);多因素logistic回归分析结果显示：UA、HCY和Cys C是PD患者认知功能障碍的独立危险因素(P<0.05)。结论 PD患者血清UA、HCY、Cys C与运动症状和认知功能相关。更多还原

【Abstract】 Objective To investigate the correlation between serum uric acid(UA), homocysteine(HCY) and cystatin C(Cys C) with motor symptoms and cognitive function in Parkinson’s disease(PD) patients. Methods A total of 200 PD patients admitted to Hebei General Hospital from January 2019 to August 2022 were enrolled. They were divided into tremor-dominant(TD) group(n=104) and non-tremor-dominant(NTD) group(n=96) according to first-onset motor symptoms. In addition, the PD patients were grouped also into cognitive normal(PD-CN) group(n=118) and cognitive impairment(PD-CI) group(n=82) according to Montreal Cognitive Assessment. The levels of serum UA, HCY and Cys C of the PD patients were compared. Multivariate logistic regression was used to analyze the risk factors of tremor and cognitive dysfunction in PD patients.Results The patients in TD group had significantly higher serum UA levels, significantly lower Hcy and Cys C levels compared with those of the NTD group(P<0.05). The results from multiple logistic regression analysis showed that UA, HCY, and Cys C were independent risk factors for tremor in PD patients. The patients in the PD-CN group pesented significantly higher serum UA levels, significantly lower HCY and Cys C levels relative to those of the PD-CI group(P<0.05). The results from multivariate logistic regression analysis verifyed that UA, HCY, and Cys C were independent risk factors for cognitive dysfunction in PD patients(P<0.05). Conclusion The serum levels of UA, HCY, and Cys C in PD patients are correlated with motor symptoms and cognitive function.更多还原