【摘要】 特应性皮炎（atopic dermatitis, AD）是一种慢性、复发性炎症性皮肤病。越来越多证据表明，皮肤屏障功能障碍是导致AD的重要原因。皮肤最外层的脂质基质角质层（stratum corneum, SC）对皮肤屏障功能的维系至关重要。大量研究显示，角质层脂质含量降低、链长度缩短、神经酰胺（ceramide, CER）亚类水平改变以及炎症反应等都会影响AD患者皮肤屏障功能。本文就角质层脂质链长度与AD患者皮肤屏障功能的关系做一综述。更多还原

【Abstract】 Atopic dermatitis(AD) is a chronic and recurrent inflammatory skin disease. There is growing evidence that skin barrier dysfunction is an important cause of AD. The lipid matrix in the outermost layer of the skin, namely the stratum corneum(SC), is essential for the skin barrier function. A large number of studies have shown that the decrease of SC lipid content, the shortening of chain length, the change of ceramide(CER) subclass levels and inflammatory responses all affect the skin barrier function of AD patients. This article reviews the relationship between the SC lipid chain length and the skin barrier function in AD patients.更多还原