【摘要】 骨髓间充质干细胞(BMMSCs)不仅是骨再生的关键细胞来源，而且可以发挥免疫调节作用，招募并调控巨噬细胞的表型和功能。巨噬细胞不仅通过清除细胞碎片、坏死组织等，为骨再生创造良好的微环境，且可通过影响BMMSCs的迁移和分化参与骨再生。调控BMMSCs与巨噬细胞间的交互作用对于骨再生具有重要意义。本文就骨再生过程中BMMSCs与巨噬细胞交互作用及其调控策略的最新进展作一综述。更多还原

【Abstract】 The bone marrow mesenchymal stem cells(BMMSCs) are not only the key cell sources for bone regeneration, but also play an immunomodulatory role by recruiting and regulating the phenotype and function of macrophages. At the same time, macrophages not only create a good microenvironment for bone regeneration by removing cell debris and necrotic tissue, but also participate in bone regeneration by affecting the migration and differentiation of BMMSCs. Therefore, the regulation of the interaction between BMMSCs and macrophages is of great significance for bone regeneration. This article reviews the recent progress of the interaction between BMMSCs and macrophages and its regulatory strategies during bone regeneration.更多还原