【摘要】 目的 评价光活化消毒（photo-activated disinfection,PAD）作为中重度慢性牙周炎辅助治疗的效果。方法 选择PD≥5 mm的慢性牙周炎后牙（共计21例，218位点），以龈下刮治及根面平整术（scaling and root planing,SRP）治疗前为基线，在SRP后分4组进行辅助治疗。A组：盐酸米诺环素；B组：PAD;C组：PAD+盐酸米诺环素；D组：无辅助治疗。在基线、治疗后6周、治疗后12周分别记录患牙探诊深度（probing depth,PD）、探诊出血（bleeding on probing,BOP）及临床附着丧失（clinical attachment loss,CAL）；同时用Real-time PCR检测3个辅助治疗组龈下菌斑中的牙龈卟啉单胞菌（porphyromonas gingivalis,Pg）和福赛坦氏菌（tannerella forsythia,Tf），观察2种牙周致病菌含量的变化情况。结果 与基线比较，4个组牙周指标在治疗后6周、12周均有显著改善（P <0.001），且A、B、C 3个辅助治疗组控制效果均明显优于无辅助治疗的D组（P <0.001）,C组对PD的改善效果优于A组（P <0.001）;3个辅助治疗组Pg、Tf的量在6周、12周均有明显下降（P <0.001），组间差异无统计学意义（P>0.05）。结论 作为SRP的辅助治疗，PAD能达到与盐酸米诺环素同等程度的临床疗效，PAD可替代盐酸米诺环素用于中重度慢性牙周炎。更多还原

【Abstract】 Objective To evaluate the effect of photo-activated disinfection(PAD) as a kind of adjuvant treatment on moderate to severe chronic periodontitis. Methods 21 patients with the chronic periodontitis(totally 218 selected sites) were randomly enrolled and divided into group A( minocycline hydrochloride),group B(PAD),group C(PAD + minocycline hydrochloride),and group D(no adjunctive therapy) for the adjunctive treatment after receiving the scaling and root planing(SRP). Periodontal indexs as probing depth(PD),bleeding on probing(BOP)and clinical attachment loss(CAL) were examined at the baseline,6 and 12 weeks after the treatment. Meanwhile,periodontal pathogens as Porphyromonas gingivalis(Pg) and Tannerella forsythia(Tf) from subgingival plaque of group A, B and C were detected by Real-time PCR. Results Compared with the baseline, the periodontal inflammations of all groups were improved signiffcantly at 6 and 12 weeks after the treatment(P < 0.001),and group A,group B and group C were better than group D(P < 0.001),group C was better than group A(P < 0.001);Furthermore,the concentration of Pg and Tf was decreased significantly(P < 0.001),and there was no difference among the three groups with adjunctive therapy. Conclussion As the adjunctive treatment of SRP,PAD could achieve the same and even better effect than minocycline hydrochloride ointment.更多还原