【摘要】 氧化应激是细胞衰老、损伤的重要机制，大量运动可导致人体多系统/器官细胞发生氧化应激损伤。益生菌补充剂具有抗氧化、免疫调节等生物功能。以高水平运动员为研究对象，通过分析益生菌补充剂对氧化应激、炎症水平及免疫状态的影响，旨在明确益生菌补充剂对运动相关的氧化应激损伤的保护作用。氧化应激指标包括血清丙二醛（MDA）、超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）水平以及血清总抗氧化能力（TAOC）；炎症指标包括血清C-反应蛋白（CRP）、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平；免疫指标包括外周血CD4+、CD8+、CD4+CD25+T细胞计数。结果显示，益生菌补充剂可提高机体SOD、GSH、TAOC和CD4+CD25+T细胞计数水平，降低MDA、TNF-α水平、CD4+和CD8+细胞计数水平，说明益生菌补充剂可改善大量运动所致的氧化应激和炎症状态，具有免疫调节功能。更多还原

【Abstract】 Oxidative stress is an important mechanism of cell aging and injury, and extensive exercise can cause oxidative stress damage to cells of multiple systems/organs in body. Probiotic supplements have many biological functions, such as antioxidant and immune regulation. This study focuses on high-level athletes, aiming to clarify the protective effect of probiotic supplements on exercise-related oxidative stress damage, by analyzing the impact of probiotic supplements on oxidative stress, inflammation levels, and immune state. Oxidative stress indicators are serum malondialdehyde(MDA), superoxide dismutase(SOD), reduced glutathione(GSH), and total antioxidant capacity(TAOC); Inflammatory markers include serum C-reactive protein(CRP) and tumor necrosis factor-α(TNF)-α, and the level of interleukin-6(IL-6); Immune indicators include peripheral blood CD4+,CD8+, and CD4+CD25+T cell counts. The results showed that probiotic supplements can increase the levels of SOD, GSH,TAOC, CD4+CD25+T cell counts, and reduce the levels of MDA, TNF-α, CD4+, and CD8+ cell counts, indicating that probiotic supplements can improve the oxidative stress and inflammation caused by extensive exercise, and improve immune regulatory functions.更多还原