【摘要】 银屑病是一种免疫介导的多基因遗传性皮肤病。该病虽基本不致命，但严重影响患者的生活质量。当前，传染的治疗措施虽然有效，但不容易达到长期的缓解。近年来，靶向生物制剂和口服小分子药物已经成为银屑病治疗的新焦点，与传统治疗方法相比，其可以更有效地调节病理性免疫反应，减轻炎症并降低复发率。该文主要从银屑病的发病机制、靶向生物制剂与口服小分子药物的研发和临床应用状况进行了综述，以期为银屑病的更好治疗提供最新视角。更多还原

【Abstract】 Psoriasis is an immune-mediated, polygenic, hereditary skin disease. Although the disease is generally not fatal, it seriously affects the living quality of patients. Presently, the treatment measures of infection are effective,but it is not easy to achieve long-term remission. In recent years, targeted biologics and oral small molecule drugs have become a new focus in the treatment of psoriasis, which can regulate pathological immune responses, reduce the inflammation and recurrence rate more effectively than traditional therapeutic methods. In this article, the pathogenesis of psoriasis, the research and development and clinical applications of targeted biologics and oral small molecule drugs are reviewed to provide the latest perspective for better treatment of psoriasis.更多还原