【摘要】 目的 分析苏州市吴江区2008—2022年的结直肠癌死亡流行病学特征及变化趋势。方法 收集吴江区户籍居民结直肠癌死亡数据，计算死亡率、标化死亡率、早死概率，进行潜在寿命损失年(PYLL)、潜在寿命损失年率(PYLLR)、平均潜在寿命损失年数(AYLL)分析，寿命表法计算去死因期望寿命(CELE)和期望寿命损失年数(YLEL)等；Joinpoint软件计算各指标平均年度变化百分比(AAPC)。结果 2008—2022年吴江区居民结直肠癌死亡率(AAPC=4.42%,P<0.01)与标化死亡率(AAPC=1.63%,P<0.05)均呈上升趋势。男性结直肠癌标化死亡率高于女性。结直肠癌死亡率35岁前处于较低水平，后随年龄增长而增加；80～<85岁组和≥85岁年龄组死亡率AAPC均呈上升趋势(P值均<0.01)。因结直肠癌导致期望寿命损失呈上升趋势(AAPC=3.58%,P<0.01);早死概率未见趋势性变化。结直肠癌PYLL为9 947.5人年，PYLLR为0.91‰,AYLL为11.53年。结论 吴江区居民结直肠癌死亡率呈上升趋势，因结直肠癌导致寿命损失逐年升高，迫切需要开展疾病早期筛查，实现早发现、早诊断、早治疗。更多还原

【Abstract】 Objective To investigate the epidemiological characteristics of and trends in mortality of colorectal cancer in Wujiang District, Suzhou City from 2008 to 2022. Methods Data pertaining to the mortality of colorectal cancer among residents with household registration in Wujiang District were collected.The mortality, standardized mortality, probability of premature mortality, potential years of life lost rate(PYLLR) and average years of life lost(AYLL) were calculated, and the cause-eliminated life expectancy(CELE) and years of life expectancy lost(YLEL) were estimated with the life table method.In addition, the trends in mortality of colorectal cancer were evaluated in Wujiang District from 2008 to 2022 using a Joinpoint regression model with average annual percent change(AAPC). Results Both the mortality(AAPC=4.42%, P<0.05) and standardized mortality of colorectal cancer(AAPC=1.63%, P<0.05) appeared a tendency towards a rise among residents in Wujiang District from 2008 to 2022,and the standardized mortality was higher among men than among women.The mortality of colorectal cancer was low among residents under the age of 35 years, then increased with age, and appeared a tendency towards a rise among residents at ages of 80 to 84 years and 85 years and older(both P values<0.01).The life expectancy lost due to colorectal cancer appeared a tendency towards a rise among residents in Wujiang District from 2008 to 2022(AAPC=3.58%, P<0.01),and no significant changes were seen in trends in the probability of premature mortality.In addition, the PYLL,PYLLR and AYLL of colorectal cancer were 9 947.5 year-persons, 0.91‰ and 11.53 year-persons, respectively. Conclusions The mortality of colorectal cancer appeared a tendency towards a rise among residents in Wujiang District from 2008 to 2022,and the life lost due to colorectal cancer gradually increased over years.Early screening is of urgent need to achieve early identification, early diagnosis and early treatment of colorectal cancer.更多还原