【摘要】 目的 分析研究经肝动脉化疗栓塞术(TACE)后发生栓塞综合征(PES)的相关影响因素。方法 选择2021年2月至2023年3月期间合肥市第一人民医院收治的107例接受TACE的肝癌患者，其中56例发生PES,纳入PES并发组，51例未发生PES,纳入PES未并发组。比较两组患者人口学资料，病史、病理资料及实验室指标、手术相关资料，分析PES发生的危险因素。结果 两组患者肿瘤直径、白蛋白(ALB)、术前体力状态(ECOG)评分、栓塞剂类型、载药微球、微球数量、载药剂量差异均有统计学意义(P<0.05)。Logistic多因素分析显示，载药微球、微球数量、载药剂量是TACE后发生PES的独立危险因素(P<0.05)。结论 使用载药微球、微球数量多、载药剂量高的肝癌患者TACE后发生PES的风险更大，围手术期对具备上述危险因素的患者制定对应干预策略可能利于规避PES发生，提高TACE安全性。更多还原

【Abstract】 Objective To analyze the factors influencing the occurrence of post-embolization syndrome(PES) after transhepatic arterial chemoembolization(TACE).Methods A total of 107 patients with hepatocellular carcinoma(HCC),who received TACE treatment at authors′ hospital between February 2021 and March 2023,were included in the study.Among them, 56 patients developed PES(PES group) and 51 patients did not develop PES(non-PES group).The demographic data, medical history, pathological findings, laboratory indicators and operation-related materials were compared between the two groups, and the risk factors for PES were analyzed.Results There were statistically significant differences in tumor diameter, albumin(ALB) level, preoperative physical condition(ECOG) score, type of embolization agent, drug-loaded microspheres, number of microspheres, and dosage of loaded drug between the two groups(all P<0.05).Multivariate Logistic analysis revealed that drug-loaded microspheres, number of microspheres, and dosage of loaded drug were the independent risk factors for PES occurring after TACE(all P<0.05).Conclusion HCC patients treated with TACE using drug-loaded microspheres, large amount of microspheres and high dosage of loaded drug have a higher risk of PES occurring after TACE.For patients having the above risk factors, the formulation of corresponding perioperative intervention strategies is necessary so as to avoid the occurrence of PES and to improve the safety of TACE.更多还原