【摘要】 目的:分析25羟维生素D水平对绝经后2型糖尿病患者颈动脉内膜中层厚度(IMT)的影响。方法:回顾性分析2021年6月—2023年7月于绵阳市中心医院就诊的75例绝经后2型糖尿病患者的临床资料。将其按照不同25羟维生素D水平分为三组,25羟维生素D <12ng/mL为维生素D缺乏组(A组),12ng/mL≤25羟维生素D<20ng/mL为维生素D不足组(B组),25羟维生素D≥20ng/mL为维生素D充足组(C组),每组25例。比较三组一般资料、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HAb1c)、25羟维生素D、空腹血糖(FPG)、舒张压、收缩压、IMT;并分析IMT的影响因素。结果:三组年龄、TG、TC、HDL-C、LDL-C、HAb1c、体质量指数(BMI)及FPG、舒张压比较,差异无统计学意义(P> 0.05);三组间收缩压、IMT、25羟维生素D比较,差异有统计学意义(P<0.05)。Pearson相关性分析显示IMT与TC、LDL-C、收缩压、年龄呈正相关(P<0.05),而与25羟维生素D呈负相关(P<0.05)。在校正相关混杂因素后,经多元线性回归分析显示25羟维生素D水平是绝经后2型糖尿病患者IMT的影响因素(P<0.05)。结论:25羟维生素D水平与绝经后2型糖尿病患者IMT独立相关,可作为动脉硬化的预测指标之一。更多还原

【Abstract】 Objective To analyze the postmenopausal patients with type 2 diabetes,25-hydroxyvitamin D levels and the correlation of carotid intima-media thickness(IMT).Methods A total of 75 postmenopausal patients with type 2 diabetes who were treated in Mianyang Central Hospital June 2021 to July 2023 were retrospectively analyzed.They were divided into 3 groups with 25 cases in each group according to different 25-hydroxyvitamin D levels,25-hydroxyvitamin D <12 ng/mL was vitamin D deficiency(group A),12 ng/mL ≤25-hydroxyvitamin D <20 ng/mL was vitamin D insufficiency(group B).25-hydroxyvitamin D> 20 ng/mL was considered adequate for vitamin D(group C).The differences of general information,triglyceride(TG),total cholesterol(TC),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),glycosylated hemoglobin(HAblc),25-hydroxyvitamin D,and fasting plasma glucose(FPG),diastolic blood pressure,systolic blood pressure,IMT among the three groups of patients were compared,and the influencing factors of IMT were analyzed.Results There were no significant differences in age,TG,TC,HDL-C,LDL-C,HAblc,FPG,body mass index(BMI) and diastolic blood pressure among the three groups(P> 0.05).Systolic blood pressure,IMT and 25-hydroxyvitamin D were significantly different among the three groups.Pearson correlation analysis showed that IMT and TC,LDL-C positively correlated systolic blood pressure,age,and negatively correlated with 25-hydroxy vitamin D(P <0.05).After adjustment for confounding factors related,the multiple linear regression analysis showed,25-hydroxyl is vitamin D levels in postmenopausal patients with type 2 diabetes independent influencing factors of IMT(P <0.05).Conclusions 25-hydroxyvitamin D level is independently associated with IMT in postmenopausal patients with type 2 diabetes,and can be used as one of the predictors of atherosclerosis.更多还原