【摘要】 目的：采用定量CT探讨健康体检人群腹部脂肪分布与高尿酸血症的关系。方法：纳入10 887例健康体检者为研究对象。将内脏脂肪面积（VFA）、皮下脂肪面积（SFA）根据Q_L、Q_U由小到大均分成4等份，分别为Q₁、Q₂、Q₃、Q₄。采用多因素logistic回归分析构建4个模型评估VFA、SFA与高尿酸血症的相关性；并根据完全调整模型，按性别因素进行分层分析。结果：高尿酸血症的总检出率为20.2%（2 196/10 887），男性检出率明显高于女性（P<0.05）。在完全调整模型中，VFA在Q₂～Q₄发生高尿酸血症的风险分别是Q₁的1.73倍（1.42～2.10）、2.44倍（1.95～3.04）、2.99倍（2.32～3.86），趋势性检验P<0.001;SFA在Q₂～Q₄发生高尿酸血症的风险分别是Q₁的0.95倍（0.82～1.11）、0.99倍（0.85～1.16）、1.17倍（0.97～1.42），趋势性检验P=0.109。不同性别的VFA Q₂～Q₄发生高尿酸血症风险的趋势性检验均P<0.05；而男性的SFA Q₂～Q₄发生高尿酸血症风险的趋势性检验P<0.05，女性中趋势性检验P>0.05。结论：健康体检人群中，VFA的增加与高尿酸血症的发生风险呈正相关，VFA可作为高尿酸血症防治的重要监测指标；对于SFA，该关联仅存在男性中。更多还原

【Abstract】 Objective:To explore the relationship between abdominal fat distribution and hyperuricemia in healthy population in physical examination by quantitative CT （QCT） technology.Methods:A total of 10,887 healthy person in physical examination were included as study subjects.Visceral fat area （VFA） and subcutaneous fat area （SFA） were divided into 4 groups according to the interquartile interval （from Q₁ to Q₄）.Multivariate logistic regression analysis was used to establish four models to assess the correlation between VFA,SFA and hyperuricemia,according to the fully adjusted model,the analysis was stratified according to gender factors.Results:The overall detection rate of hyperuricemia was 20.2%,the detection rate of male was significantly higher than that of female（P<0.05）.In the fully adjusted model,the risk of hyperuricemia in Q₂,Q₃,Q₄group of VFA was 1.73（1.42～2.10）,2.44（1.95～3.04） and 2.99（2.32～3.86） times as compared with Q₁ group,respectively,trend test P<0.001.The risk of hyperuricemia in Q₂,Q₃,Q₄ group of SFA was 0.95（0.82～1.11）,0.99（0.85～1.16） and1.17（0.97～1.42） times as compared with Q₁ group,respectively,trend test P=0.109.Trend test P values of the risk of hyperuricemia in VFA Q₂,Q₃,Q₄ group were less than 0.05 in both men and women,while trend test P values of the risk of hyperuricemia in VFA Q₂,Q₃,Q₄ group were less than 0.05 in men,but greater than 0.05 in women.Conclusions:In the healthy population in physical examination,the increase of VFA is positively correlated with the risk of hyperuricemia,and VFA can be used as an important monitoring indicator for the prevention and treatment of hyperuricemia,while the association between SFA hyperuricemia is found only in men.更多还原