【摘要】 目的：利用fMRI研究运动成瘾人群的奖赏与抑制功能神经网路。方法：采用运动成瘾量表（EAI）筛选出29例运动成瘾者（成瘾组），平均年龄（45.6±4.3）岁；招募26例性别、年龄、平均受教育水平相匹配的非运动成瘾者（对照组），平均年龄（45.7±5.6）岁。采用相关线索刺激和Go/NoGo行为任务范式；2组在观看运动相关图片和执行Go/NoGo任务下行fMRI扫描。结果：线索刺激脑激活状态分析结果显示，成瘾组在观看运动图片时奖赏网络激活显著增强，表现为左侧额上回、左侧额中回、左侧额下回和右侧前扣带皮质脑区活动增强。Go与NoGo任务条件下的脑激活状态对比显示，对照组存在显著的抑制性负激活脑区，包括右侧颞上回、右侧中央后回、左侧中央后回、左侧缘上回、右侧中央前回等（均P<0.01），而成瘾组仅显示左侧中央后回的负激活显著（P<0.01）。结论：运动成瘾人群对运动线索刺激的奖赏网络激活显著增强，而执行神经网络的抑制功能反应明显减弱。更多还原

【Abstract】 Objective:To study the neural networks of reward and inhibitory in people with exercise addiction by fMRI.Methods:The exercise addiction inventory(EAI) was used to screen 29 exercise addicted individuals(the addiction group) and 26 individuals without addiction(the control group),who were matched for gender,age and education level. The cue-related stimulation and the Go/NoGo behavior tasks were applied,and all subjects underwent fMRI during task performance.Results:The analysis of brain activation state with the cue-related stimulation showed that,when the patients in the addiction group were stimulated with moving pictures,the activation of the reward network,including the left upper frontal gyrus,the left middle frontal gyrus,the left inferior frontal gyrus and the right anterior cingulate cortex,increased significantly. The comparison of brain activation state with Go and NoGo tasks showed that,the control group had more brain regions with significant inhibitory negative activation,including the right superior temporal gyrus,the right postcentral gyrus,the left postcentral gyrus,the left supramarginal gyrus and the right precentral gyrus,while the addiction group had one brain region of the left postcentral gyrus(P<0.01). Conclusions:The reward network activation in the exercise addicted people stimulated by sports cues is significantly greater,while the inhibitory functional responses of the executive neural network are obviously weakened.更多还原