【摘要】 目的 探析甲磺酸阿帕替尼对晚期卵巢癌(advanced ovarian cancer, AOC)患者的临床效果及对人附睾蛋白4(HE4)、血清甲胎蛋白(AFP)、糖类抗原724(CA724)及糖类抗原125(CA125)的影响。方法 将2020年9月—2022年10月在南阳市中心医院进行治疗的98例晚期卵巢癌患者作研究对象，随机数字表法对其进行分组(观察组与对照组),均49例。对照组实施紫杉醇+卡铂化疗，观察组基于对照组基础之上加用甲磺酸阿帕替尼疗法，对比两个组患者治疗结果及血清肿瘤标志物变化情况。结果 观察组患者治疗有效率(85.71%)优于对照组(63.27%),组间数据比较差异有统计学意义(P<0.05)。观察组患者不良反应发生率14.29%,对照组患者的不良反应率36.73%,两组数据对比差异有统计学意义(P<0.05)。观察组患者的血清肿瘤标志物[附睾蛋白4(HE4)、甲胎蛋白(AFP)、糖类抗原724/125(CA724)/(CA125)]水平优于对照组，差异有统计学意义(P<0.05)。结论 AOC患者应用用阿帕替尼进行治疗，能够很好缓解肿瘤标志物的水平，进一步提升治疗的效果，减少不良反应情况的发生，综合效果佳，建议临床推广使用。更多还原

【Abstract】 Objective To investigate the clinical effect of Apatinib mesylate on patients with advanced ovarian cancer(AOC) and its effects on human epididymal protein 4(HE4), serum alpha-fetoprotein(AFP), carbohydrate antigen 724(CA724) and carbohydrate antigen 125(CA125).Methods Totally 98 patients with advanced ovarian cancer who were treated in our hospital from September 2020 to October 2022 were selected as research objects, and they were divided into 49 patients(observation group and control group) by random number table method. The control group received paclitaxel and carboplatin chemotherapy, and the observation group received apatinib mesylate therapy based on the control group. The treatment results and serum tumor markers of the two groups were compared.Results The effective rate of the observation group was 85.71%, which was better than that of the control group was 63.27%, with significant difference between groups(P<0.05). The incidence of adverse reactions was 14.29% in observation group and 36.73% in control group, and the difference between the two groups was statistically significant(P<0.05). The levels of serum tumor markers[epididymal protein 4(HE4), alpha-fetoprotein(AFP), carbohydrate antigen 724/125(CA724)/(CA125)] in observation group were better than those in control group, and the difference was statistically significant(P<0.05).Conclusion The application of apatinib in the treatment of AOC patients can effectively alleviate the level of tumor markers, further improve the therapeutic effect and reduce the occurrence of adverse reactions, and the comprehensive effect is good, suggesting clinical promotion and use.更多还原