【摘要】 目的 探讨乙型肝炎病毒(HBV)感染相关性肝细胞癌(HCC)患者血甲胎蛋白(AFP)、转氨酶水平与HBV-DNA载量和病情进展的关系。方法 回顾性分析2022年1月至2023年4月本院收治的50例HBV感染相关性HCC患者资料并设为HCC组，另筛选同期HBV相关肝硬化(LC)和慢性乙型肝炎(CHB)患者资料各30例设为L C组和CHB组，比较三组血AFP及转氨酶水平；比较HCC组不同HBV-DNA载量患者AFP及转氨酶水平差异，并分析肝癌组患者AFP及转氨酶水平与病情进展的关系。结果 HCC组患者AFP和丙氨酸氨基转移酶(ALT)水平均高于CHB组和LC组(P<0.05);50例HCC患者中，中低分化及Ⅲ～Ⅳ期患者血AFP和ALT水平高于高分化及Ⅰ～Ⅱ期患者(P<0.05);HBV-DNA高载量患者血AFP和ALT水平高于低载量患者(P<0.05)，且患者HBV-DNA载量与其血AFP和ALT水平呈正相关(P<0.05)。结论 HBV感染相关性HCC患者血AFP和ALT水平显著提升，且血AFP和转氨酶水平与HBV-DNA载量、肿瘤分期分化程度关系密切，二者对临床评估HBV感染相关性HCC病情进展有一定提示作用。更多还原

【Abstract】 Objective To explore the relationship between serum alpha-fetoprotein(AFP), aminotransferase and HBV-DNA load, disease progression in patients with hepatitis B virus(HBV) infection-associated hepatocellular carcinoma(HCC). Methods A retrospective analysis was performed on the data of 50 patients with HBV infection-associated HCC(HCC group) admitted to the hospital between January 2022 and April 2023, while 30 patients with HBV infection-associated liver cirrhosis(LC) and 30 patients with chronic hepatitis B(CHB) during the same period were enrolled as LC group and CHB group. The levels of AFP and aminotransferase were compared among the three groups and in HCC patients with different HBVDNA loads. The relationship between AFP, aminotransferase levels and disease progression in HCC group was analyzed. Results The levels of AFP and alanine aminotransferase(ALT) in HCC group were higher than those in CHB group and LC group(P<0.05). Among the 50 patients with HCC, levels of AFP and ALT in patients with low-moderate differentiation and stages III-IV were higher than those with high differentiation and stages I-II(P<0.05). The levels of AFP and ALT in patients with high HBV-DNA load were higher than those with low load(P<0.05). HBV-DNA load was positively correlated with levels of serum AFP and ALT(P<0.05). Conclusion The levels of serum AFP and ALT are significantly increased in patients with HBV infection-associated HCC, and which are closely related to HBV-DNA load, tumor staging and differentiation degree. Clinically, the two indexes have certain evaluation value for progression of HBV infection-associated HCC.更多还原