【摘要】 【目的】探讨类风湿性关节炎患者外周血胰岛素样生长因子-2(IGF-2)及胰岛素样生长因子结合蛋白-6(IGFBP-6)水平与疾病活动度的相关性。【方法】本院收治的158例类风湿性关节炎患者,根据28个关节疾病活动性评分分为高度活动组、中度活动组和轻度活动组,比较三组患者外周血IGF-2及IGFBP-6水平;分析疾病不同活动度与外周血IGF-2及IGFBP-6表达水平的关系及疾病活动度的影响因素。【结果】158例类风湿性关节炎患者中高度活动组61例(38.61%),中度活动组59例(37.34%),轻度活动组38例(24.05%)。高度活动组外周血IGF-2水平高于中度及轻度活动组,IGFBP-6水平低于中度及轻度活动组,中度活动组外周血IGF-2水平高于轻度活动组,IGFBP-6水平低于轻度活动组,且差异均有统计学意义(P <0.05)。患者疾病活动度与外周血IGF-2表达水平呈负相关(P <0.001),与外周血IGFBP-6表达水平呈正相关(P <0.001)。多因素分析显示,白细胞计数(WBC)及IGF-2表达水平偏高,IGFBP-6表达水平偏低均为类风湿性关节炎患者病情高度活动性的危险因素(P <0.05)。【结论】高度活动类风湿性关节炎患者外周血IGF-2表达水平较高,与疾病活动度呈负相关;IGFBP-6表达水平较低,与疾病活动度呈正相关。更多还原

【Abstract】 【Objective】To investigate the correlation of disease activity with levels of insulin-like growth factor-2(IGF-2) and insulin-like growth factor binding protein-6(IGFBP-6) in the peripheral blood of patients with Rheumatoid Arthritis(RA).【Methods】A total of 158 RA patients treated in our hospital were divided into high activity,moderate activity,and low activity groups based on the disease activity score of 28 joints.The levels of IGF-2 and IGFBP-6 in the peripheral blood of the three groups were compared.The relationship of different disease activities with the expression levels of IGF-2 and IGFBP-6 was evaluated;And the influencing factors of disease activity were analyzed as well.【Results】Among the 158 RA patients,61(38.61%) were in the high activity group,59(37.34%) in the moderate activity group,and 38(24.05%) in the low activity group.The IGF-2 level in the high activity group was higher than that in the moderate and low activity groups,while the IGFBP-6 level was lower than that in the moderate and low activity groups.The moderate activity group’s IGF-2 level was higher than that of the low activity group,and the IGFBP-6 level was lower than that of the low activity group,with significant differences(P <0.05).There was a negative correlation of the disease activity with the expression level of IGF-2(P <0.001),and a positive correlation with the expression level of IGFBP-6( P <0.001).Multifactorial analysis showed that high white blood cell count,high expression level of IGF-2,and low expression level of IGFBP-6 were risk factors for high disease activity in RA patients(P <0.05).【Conclusion】In RA patients with high disease activity,the expression level of IGF-2 in peripheral blood is higher,which is negatively correlated with disease activity;And the expression level of IGFBP-6 in RA patients with high disease activity is lower,which is positively correlated with disease activity.更多还原