【摘要】 【目的】探讨户外有氧运动联合阿立哌唑对老年肥胖精神分裂症(SCH)患者脂质代谢及事件相关电位(P300)的影响。【方法】选择2019年7月至2021年7月本院收治的114例老年肥胖SCH患者,采用随机数字表法将其分为对照组、观察组,每组57例。对照组给予阿立哌唑治疗,观察组在对照组的基础上联合户外有氧运动治疗。比较两组临床疗效、精神病评定量表(BPRS)评分、社会功能评定量表(SSPI)评分、P300(潜伏期、波幅)、脂质代谢指标【甘油三酯(TG)、谷氨酸(GLU)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)】及不良反应发生情况。【结果】观察组临床有效率为94.74%,高于对照组的80.70%,差异有统计学意义(P <0.05)。治疗后,两组BPRS评分低于治疗前,且观察组低于对照组(P <0.05);两组SSPI评分高于治疗前,观察组高于对照组(P <0.05)。治疗后,两组P300潜伏期低于治疗前,观察组低于对照组(P <0.05);治疗后,两组P300波幅高于治疗前,观察组高于对照组(P <0.05)。治疗后,两组GLU、TG、LDL-C水平高于治疗前,观察组升高幅度小于对照组(P<0.05);治疗后,两组HDL-C水平低于治疗前,观察组降低幅度小于对照组(P <0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】阿立哌唑联合户外有氧运动治疗老年肥胖SCH效果显著,能改善患者临床症状,促进社会功能重建,调节脂质代谢,值得临床借鉴。更多还原

【Abstract】 【Objective】To explore the effects of outdoor aerobic exercise combined with aripiprazole on lipid metabolism and event related potential(P300) in elderly obese patients with schizophrenia(SCH).【Methods】A total of 114 elderly obese SCH patients admitted to our hospital from July 2019 to July 2021 were selected and randomly divided into a control group and an observation group using a random number table method,with 57 cases in each group.The control group was treated with aripiprazole,while the observation group received outdoor aerobic exercise treatment in addition to the control group.We compared the clinical efficacy,BPRS scores,SSPI scores,P300(latency,amplitude),lipid metabolism indicators 【triglycerides(TG),glutamic acid(GLU),low-density lipoprotein(LDL-C),high-density lipoprotein(HDL-C)】,and incidence of adverse reactions between two groups.【Results】The clinical effective rate of the observation group was 94.74%,which was higher than the control groups 80.70%,and the difference was statistically significant(P<0.05).After treatment,the BPRS scores of both groups were lower than before treatment,and the observation group was lower than the control group(P <0.05);The SSPI scores of the two groups were higher than before treatment,and the observation group was higher than the control group(P <0.05).After treatment,the P300 latency in both groups was lower than before treatment,and the observation group was lower than the control group(P <0.05);After treatment,the amplitude of P300 waves in both groups was higher than before treatment,and the observation group was higher than the control group(P <0.05).After treatment,the levels of GLU,TG,and LDL-C in both groups were higher than before treatment,and the increase in the observation group was smaller than that in the control group(P <0.05);After treatment,the HDL-C levels in both groups were lower than before treatment,and the decrease in the observation group was smaller than that in the control group(P <0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】 The combination of aripiprazole and outdoor aerobic exercise has a significant effect on the treatment of elderly obese SCH,which can improve clinical symptoms,promote social function reconstruction,regulate lipid metabolism,and is worthy of clinical reference.更多还原