【摘要】 视神经脊髓炎谱系疾病(NMOSD)是一种由自身免疫介导的主要累及视神经和脊髓的中枢神经系统炎性脱髓鞘疾病，好发于青壮年，女性居多，临床特征包括反复发作的视神经炎和横贯性脊髓炎，致残率高。补体系统(CS)激活是NMOSD发病的关键环节，因此补体抑制剂有可能成为一种新的NMOSD治疗方案。目前部分补体抑制剂药物已被用于临床试验研究。本文就近年来补体抑制剂治疗NMOSD的研究进展进行综述。更多还原

【Abstract】 Neuromyelitis optica spectrum disorders(NMOSD) are a group of primary central nervous system inflammatory demyelinating diseases mediated by autoimmunity, predominantly affecting the optic nerves and the spinal cord. It commonly occurs in young and middle-aged adults, with a higher prevalence in females. Clinical characteristics include recurrent episodes of optic neuritis and transverse myelitis, leading to a high rate of disability. The activation of the complement system(CS) is a critical step in the onset of NMOSD. Thus, complement inhibitors might emerge as a new treatment strategy for NMOSD. Currently, several complement inhibitors are under clinical trial investigation. This article reviews the recent advancements in the treatment of NMOSD with complement inhibitors.更多还原