【摘要】 目的 分析外周T细胞淋巴瘤(PTCL)的临床特征、生存和预后影响因素。方法 回顾性分析253例PTCL患者的临床特征、生存和预后影响因素等资料。采用Kaplan-Meier法进行生存分析，log-rank检验进行组间比较，Cox比例风险回归模型进行单因素及多因素分析。结果 253例患者中位年龄为60岁，3、5、10 a的疾病无进展生存(PFS)率分别为43.70%、36.60%和20.60%,3、5和、10 a的总生存(OS)率分别为56.60%、49.20%和30.00%。多因素Cox分析结果回示，Ann Arbor分期(HR=3.600, 95%CI=1.277～10.145,P=0.015)是PFS独立的不良预后因素，Ann Arbor分期(HR=4.812, 95%CI=1.389～16.679,P=0.013)和国际预后指数评分(HR=0.308, 95%CI=0.109～0.870,P=0.026)是OS独立的不良预后因素。GDPT方案组患者的总反应率、PFS率和OS率明显高于CHOP方案组(P=0.033、0.011、0.042)。结论 Ann Arbor分期和IPI评分是影响PFS和OS的预后因素，GDPT是一种具有前景的新方案，有望成为PTCL的一线疗法。更多还原

【Abstract】 Objective To analyze the clinicopathological features, survival outcomes and prognostic factors of peripheral T-cell lymphoma(PTCL). Methods Clinicopathological features, survival outcomes and prognostic factors of PTCL were retrospectively analyzed in 253 patients. Survival analysis was performed by Kaplan-Meier method, and differences between the study groups were compared by the log-rank test. The clinical and laboratory indicators were estimated with univariate and multivariate analyses by Cox proportional hazard model. Results The median age of the 253 patients was 60 years old, the 3-year, 5-year and 10-year progression free survival(PFS) rates were 43.70%, 36.60% and 20.60%, respectively, the 3-year, 5-year and 10-year overall survival(OS) rates were 56.60%, 49.20% and 30.00%, respectively. By multivariate Cox regression analysis, independent unfavorable prognostic factors for PFS was Ann Arbor stage(HR=3.600, 95% CI=1.277-10.145, P=0.015), and independent unfavorable prognostic factors for OS were Ann Arbor stage(HR=4.812, 95% CI=1.389-16.679, P=0.013) and international prognostic index score(HR=0.308, 95% CI=0.109-0.870, P=0.026). In the GDPT regimen group, the overall response rate, the rates of PFS and OS were significantly higher than the CHOP regimen group(P=0.033, 0.011, 0.042). Conclusion Ann Arbor stage and IPI score were prognostic factors for PFS and OS. The GDPT is a promising new regimen and may become the first-line therapy for PTCL.更多还原