【摘要】 目的 检索并获取预防连续性肾脏替代治疗体外循环凝血非药物抗凝干预的最佳证据。方法 系统检索UpToDate、PubMed、Cochrane Library、中国知网、万方数据库等数据库中关于预防连续性肾脏替代治疗体外循环凝血非药物抗凝干预的证据，检索时限为建库至2023年7月31日。循证团队进行文献筛选、质量评价，并提取、汇总证据。结果 共纳入16篇文献，其中指南4篇，系统评价6篇，专家共识3篇，专家意见3篇，共汇总出针对团队、血管通路、机器、护理操作、患者5个方面的非药物抗凝干预建议，共23条最佳证据。结论 该研究总结了目前预防连续性肾脏替代治疗体外循环凝血非药物抗凝干预的最佳证据，为规范护士对重症患者实施连续性肾脏替代治疗护理行为提供循证依据，有利于进一步提高重症患者连续性肾脏替代治疗的充分性。更多还原

【Abstract】 Objective To search and obtain the best evidence for non-pharmacological anticoagulant interventionfor preventing clotting of extracorporeal circuits during CRRT.Methods We searched databases(Up To Date,Pub Med,Cochrane Library,CNKI,Wanfang database,etc) to collect relevant clinical evidences related to non-pharmacological anticoagulant intervention for preventing clotting of extracorporeal circuits during CRRT. Theretrieval time was from the establishment of the database to July 31,2023. Two investigators independently screenedthe literature,evaluated the quality of the literatures,extracted and integrated the evidence.Results A total of 16articles were included in this study,including 4 guidelines,6 systematic reviews,3 expert consensuses,and 3 expertopinions. A total of 23 best evidences were summarized from 5 aspects,including team factors,vascular accessfactors,machine factors,operation-related factors,and patient factors.Conclusion This study summarizes the bestevidence of non-pharmacological anticoagulant intervention for preventing clotting of extracorporeal circuits duringCRRT,and provides evidence-based basis for standardizing nurses’ CRRT nursing behavior for critically ill patients,and further improves the sufficiency of CRRT for critically ill patients.更多还原