【摘要】 目的:经鼻高流量湿化氧疗在有创通气撤机中的应用研究。方法:选取2021年7月至2023年12月收治的60例有创通气撤机患者为研究对象，分为常规组30例、研究组30例（随机数字表法）,常规组采用传统气泡式湿化鼻导管吸氧方式，研究组采用经鼻高流量湿化氧疗，对比两组24～48h再插管率、有创通气撤机成功率、ICU住院时间等指标。结果:研究组临床指标水平优于常规组（P<0.05）;研究组24h重插管率、48h重插管率均较常规组低，有创通气撤机成功率较常规组高（P<0.05）;两组pH比较无差异（P>0.05）,研究组干预后PaO₂水平较常规组表达高，PaCO₂水平较常规组表达低（P<0.05）;研究组干预后心率、呼吸频率均低于常规组（P<0.05）。结论:经鼻高流量湿化氧疗，可有效改善患者临床指标，降低重插管率，提高有创通气撤机成功率，进而改善患者气道状态，心率与呼吸频率，值得推广。更多还原

【Abstract】 Objective:To study the application of nasal high flow humidified oxygen therapy in invasive ventilation withdrawal. Methods:Sixty patients with invasive ventilation withdrawal from July 2021 to December 2023 were selected as the study objects, and were divided into the conventional group（30 cases） and the study group（30 cases）（random number table method）. The conventional group received traditional bubble humidification nasal catheter oxygen inhalation, and the study group received nasal high-flow humidification oxygen therapy. The rate of re-intubation, successful rate of invasive ventilation withdrawal and length of ICU stay were compared between the two groups in 24～48h. Results:The clinical indicators of the research group were better than those of the conventional group（P<0.05）; The 24-hour and 48-hour re intubation rates in the research group were lower than those in the control group, and the success rate of invasive ventilation weaning was higher than that in the control group（P<0.05）; There was no significant difference in pH between the two groups（P>0.05）. After intervention, the PaO₂ level in the study group was higher than that in the control group, while the PaCO₂ level was lower than that in the control group（P<0.05）; After intervention, the heart rate and respiratory rate of the research group were lower than those of the control grou（P<0.05）. Conclusion:Nasal high-flow humidified oxygen therapy can effectively improve the clinical indicators of patients, reduce the rate of reintubation, increase the success rate of invasive ventilation withdrawal, and then improve the airway status, heart rate and respiratory rate of patients, which is worth promoting.更多还原