【摘要】 婴儿癫痫性痉挛综合征(IESS)是最近几年提出的一个新概念，是一种独特的、具有年龄特异性的难治性癫痫综合征。近年来，随着分子生物学、神经免疫学的发展以及抗癫痫药物抗痫机制的深入研究，在IESS的定义及治疗方面，取得了一些成果。目前传统抗癫痫药物的使用日趋减少。新型抗癫痫药物有增加趋势。本文查阅近几年来相关文献，从IESS的发病机制、流行病学、病因、诊断方法、治疗手段、治疗药物、临床进展，以及有效性和安全性等方面进行综述，以介绍IESS的研究现状和已有成果。更多还原

【Abstract】 Infantile epileptic spasm syndrome(IESS) is a new concept proposed recently. IESS is a unique and age-specific refractory epilepsy syndrome. The recent advances in molecular biology, neuroimmunology and the in-depth study of anti-epileptic mechanism in antiepileptic drugs have led to the achievements in the definition and treatment of infantile epileptic spasm. At present, the use of traditional antiepileptic drugs is decreasing, while the use of new antiepileptic drugs is increasing. In this paper, based on the relevant literature in recent years, the authors discuss the pathogenesis, epidemiology, etiology, diagnosis, treatment, therapeutic drugs, clinical progress, efficacy, and safety of infantile epileptic spasm, hoping to introduce the latest status in research and achievements of IESS.更多还原