【摘要】 硬质透气性角膜接触镜(RGP)以其高透氧性和安全性,在视力矫正和特定眼科疾病治疗方面发挥着重要作用。但是因RGP材料本身的疏水性导致的一系列眼部的不适限制了RGP的广泛使用。作者采用亲水单体N,N-二甲基丙烯酰胺(DMA)及N-乙烯吡咯烷酮(NVP)共聚对RGP材料进行亲水改性,其中DMA添加量为9%及NVP添加量在13%时可以有效地将接触角从100°分别降低至83°和85°左右,同时可将硬度从78 HD提升至85 HD,透光率均高于95%,DMA-9的透氧值为215 barrers,NVP-13的透氧值为192 barrers。进一步从萃取率、体外细胞毒性等方面评估,证实DMA-9与NVP-13对RGP生物相容性良好。研究证明了利用亲水性单体共聚对RGP材料进行亲水改性的可行性。更多还原

【Abstract】 Rigid gas permeable contact lenses( RGP) play an important role in vision correction and the treatment of specific ophthalmic diseases due to their high oxygen permeability and safety. However, the hydrophobicity of the RGP material itself, which leads to a range of ocular discomfort, has limited the widespread use of RGP. In this study, the hydrophilic monomers DMA and NVP copolymerization were used to hydrophilically modify RGP materials, in which the addition of 9% DMA and 13% NVP could effectively reduce the contact angle from 100°to about 83° and 85°, respectively, the hardness could be increased from 78 HD to 85 HD, and the light transmittance was higher than 95%, and the oxygen transmittance of DMA-9 was 215 barrers, and that of NVP-13 was 192 barrers. Further evaluation in terms of extraction rate and in vitro cytotoxicity confirmed that DMA-9 and NVP-13 was biocompatible with RGP. The feasibility of hydrophilic modification of RGP materials using hydrophilic monomer copolymerization was demonstrated.更多还原