【摘要】 目的 观察慢性心力衰竭(CHF)不同中医证型与脑钠肽(BNP)和左心室射血分数(LVEF)的相关性。方法 收集CHF患者240例，所有病例均进行中医辨证分型，其中阳气亏虚血瘀型32例(13.33%),气阴两虚血瘀型34例(14.17%),气虚血瘀型174例(72.50%),兼痰饮70例。比较不同中医证型的BNP和LVEF,并分析各中医证型与BNP和LVEF的相关性。结果 阳气亏虚血瘀型与气阴两虚血瘀型、气虚血瘀型患者BNP水平比较差异有统计学意义(P<0.01),气阴两虚血瘀型与气虚血瘀型患者BNP水平比较差异无统计学意义(P>0.05);阳气亏虚血瘀型患者与气阴两虚血瘀型、气虚血瘀型患者LVEF水平比较差异有统计学意义(P<0.01),气阴两虚血瘀型与气虚血瘀型患者LVEF水平比较差异无统计学意义(P>0.05)。CHF中医证型与BNP、LVEF有一定相关性。结论 CHF早期，中医证型为气虚血瘀证、气阴两虚血瘀证，晚期为阳气亏虚血瘀证。在阳气亏虚血瘀证阶段，BNP升高，LVEF值下降，在CHF晚期患者中有着同步性变化，故BNP、LVEF值可作为CHF阳气亏虚血瘀证的客观诊断指标。更多还原

【Abstract】 Objective To investigate the correlation between traditional Chinese medicine(TCM) syndrome type with brain natriuretic peptide(BNP) and left ventricular ejection fraction(LVEF) in chronic heart failure(CHF). Methods Two hundred and forty CHF patients including 32 cases(13.33%) of Yang Qi deficiency and blood stasis type, 34 cases(14.17%) of Qi and Yin deficiency and blood stasis type, 174 cases(72.50%) of Qi deficiency and blood stasis type, and 70 cases of phlegm type. All cases were classified by TCM differentiation type. The levels of BNP and LVEF were compared in patients with different TCM type, the correlation between TCM syndrome type with BNP and LVEF was analyzed. Results There was a statistically significant difference in BNP levels and LVEF score in patients with Yang Qi deficiency and blood stasis type versus patients with Qi and Yin deficiency and blood stasis type(both P<0.01), and patients with Yang Qi deficiency and blood stasis type versus Qi deficiency and blood stasis type(both P<0.01). There was no statistically significant difference in BNP levels and LVEF score in patients with Qi and Yin deficiency and blood stasis type versus patients with Qi deficiency and blood stasis type(both P>0.05). There was a certain correlation between TCM syndromes with BNP and LVEF in CHF. Conclusion TCM syndrome type of patients with early CHF is Qi deficiency and blood stasis syndrome, and Qi and Yin deficiency and blood stasis syndrome, and which of patients with advanced CHF is Yang Qi deficiency and blood stasis syndrome. The increased BNP and decreased LVEF value have found in patients with Yang Qi deficiency and blood stasis syndrome, which have synchronous changes in patients with advanced CHF. BNP, LVEF value can as objective indicators for CHF with Yang Qi deficiency and blood stasis syndrome.更多还原