【摘要】 目的 探讨加速康复外科(enhanced recovery after surgery, ERAS)模式联合口服碳水化合物对结直肠癌患者围术期康复效果。方法 选取2019年1月至2021年1月收治的73例结直肠癌患者作为研究对象，随机分为口服碳水化合物组(A组，36例)和口服碳水化合物+ERAS模式组(B组，37例),将2组各项围手术期数据纳入软件处理，比较2组围术期康复疗效差异。结果 A组手术后1、3 d时的MTL低于B组，7 d时的MTL高于B组(P<0.05);A组手术后1 d时的IGF-1低于B组，3、7 d时的IGF-1高于B组(P<0.05);A组手术后1、3 d时的DAO高于B组(P<0.05);2组组内手术前后的MTL、IGF-1、DAO相比差异显著(P<0.05)。A组的口渴、饥饿、焦虑等主观舒适度评分较B组更高(P<0.05)。A组术后总并发症发生率为27.78%(10.36),B组为13.51%(5/37),A组术后总并发症发生率(27.78%)较B组(13.51%)相比更高(P<0.05)。结论 口服碳水化合物联合ERAS模式能有效促进结直肠癌患者围手术期胃肠功能恢复，减少肠粘膜屏障损伤，提高主观舒适度，降低术后并发症，安全性好。更多还原

【Abstract】 Objective To investigate the effect of oral carbohydrate combined with enhanced recovery after surgery(ERAS) on perioperative rehabilitation of patients with colorectal cancer(CC). Methods A total of 73 CC patients admitted from January 2019 to January 2021 were randomly divided into oral carbohydrate group(group A, 36 cases) and oral carbohydrate + ERAS mode group(group B, 37 cases). The perioperative data of the two groups were introduced in SPSS 21.0 software to compare the perioperative rehabilitation efficacy between the two groups. Results Motilin(MTL) at day 1 and day 3 postoperatively in group A was significantly lower than that of group B, and MTL at day 7 was significantly higher(P<0.05). Insulin growth factor 1(IGF-1) at day 1 postoperatively in group A was significantly lower than that of group B, and IGF-1 at day 3 and day 7 was significantly higher(P<0.05). Diamine oxidase(DAO) at day 1 and day 3 postoperatively in group A was significantly higher than that of group B(P<0.05). There were significant differences in MTL, IGF-1 and DAO before and after treatment between groups(P<0.05).The subjective comfort scores of thirst, hunger and anxiety in group A were significantly higher than those of group B(P< 0.05). The total postoperative complication rate in group A was significantly higher than that of group B(27.78% vs 13.51%, P<0.05).Conclusion Oral carbohydrate combined with ERAS can effectively promote the recovery of gastrointestinal function in CC patients alleviate the injury of intestinal mucosal barrier, improve subjective comfort, and reduce postoperative complications.更多还原