【摘要】 目的 分析慢性阻塞性肺疾病急性加重合并糖尿病的临床特征分析。方法 收集被诊断为慢性阻塞性肺疾病急性加重患者182例，将其分为糖尿病组及单纯COPD组。记录患者的基线资料、肺功能、炎症指标及共患病、1秒量（FEV1）、1秒量占预计值比例（FEV1%）、用力肺活量（FVC）、1秒率（FEV1/FVC）、血常规、C反应蛋白（CRP）、降钙素原（PCT）、纤维蛋白原（Fib）、改良英国医学研究理事会呼吸困难指数（mMRC）等资料分别与二氧化碳分压（PaCO₂）的相关性进行分析。结果 糖尿病组发生Ⅱ型呼吸衰竭的患者20（27.0%）较单纯COPD组8（7.4%）高，急性加重期糖尿病组的FEV1（L）（1.07±0.42）、FEV1（%）（47.8.00±16.80）较单纯COPD组的（1.28±0.41）、（57.39±21.51）低；AECOPD的PaCO₂与FEV1相关系数是-0.462，与FEV1%、FVC、FVC%相关系数分别是-0.410、-0.448、-0.396,P均<0.001，与FEV/FVC无明显关系，相关系数是0.188,P值0.074。结论 AECOPD的糖尿病患者有更低的FEV1、FEV1%、FVC、FVC%,PaCO₂严重程度与FEV1、FEV1%、FVC等呈中度负相关关系，与FVC%呈轻度负相关关系。更多还原

【Abstract】 Objective To analyze the clinical features of patients with acute exacerbation chronic obstructive pulmonary disease（COPD）.Methods 182 patients admitted to the respiratory Department of Guangzhou Red Cross Hospital who were diagnosed with acute exacerbation of COPD were collected and divided into diabetes group and simple COPD group.Baseline data,pulmonary function,inflammatory markers and comorbidity,one-second dose（FEV1）,proportion of one-second dose to expected value（FEV1%）,forced vital capacity（FVC）,one-second rate（FEV1/FVC）,blood routine,C-reactive protein（CRP）,procalcitonin（PCT）,fibrinogen（Fib）,and modified British Medical Research Protocol were recorded The correlation between the activity dyspnea index（mMRC）and the partial pressure of carbon dioxide（PaCO₂） was analyzed.Results The incidence of type 2 respiratory failure in the diabetes group was 20 patients（27.0%）,higher than that in the COPD group alone 8（7.4%）.FEV1（L）of 1.07±0.42 and FEV1（%）of 47.8.00±16.80 in acute aggravated diabetes group were lower than those in simple COPD group（1.28±0.41 and 57.39±21.51）.The correlation coefficient between PaCO₂ and FEV1 of AECOPD was-0.462,and the correlation coefficient between PACO₂ and FEV1%,FVC and FVC% were-0.410,-0.448 and-0.396,respectively,with P values <0.001,and there was no obvious relationship between PACO₂ and FEV/FVC,with the correlation coefficient being 0.188 and P value 0.074.Conclusions Diabetic patients with AECOPD have lower FEV1,FEV1%,FVC and FVC%,and the severity of PaCO₂ is moderately negatively correlated with FEV1,FEV1% and FVC,and slightly negatively correlated with FVC%.更多还原