【摘要】 以芦丁为起始原料，以5-（4-羟基苯基）-3H-1,2-二硫杂环戊烯-3-硫酮作为H₂S供体，合成一种具有治疗糖尿病且促进伤口愈合功能的药物槲皮素-3-O-乙酸-（4-（3H-1,2-二硫杂环戊烯-3-硫酮））-苯酯。整个工艺路线包括取代、水解、williamson醚化、水解和酯化等5步反应，总产率为6.4%。各步产物经MS、¹H NMR分析表征。该合成路线具有原料廉价易得、反应条件温和、操作简便的优点。更多还原

【Abstract】 A drug quercetin-3-O-acetic acid-（4-（3H-1,2-dithiacyclopentene-3-thione））-phenyl ester with the function of treating diabetes and promoting wound healing was synthesized by using rutin as the starting material and 5-（4-hydroxyphenyl）-3H-1, 2-dithiacyclopentene-3-thione as the H₂S donor. The whole process route included a total of five reaction steps including substitution, hydrolysis, williamson etherification, hydrolysis, and esterification, with a total yield of 6.4%. The products of each step were characterized by MS and ¹H NMR analysis. The synthetic route has the advantages of cheap and easy availability of raw materials, mild reaction conditions and simple operation.更多还原