【摘要】 目的：探究内分泌治疗联合多西他赛化疗对前列腺癌患者安全性及有效性的影响。方法：选取我院2020年1月至2023年6月纳入的120例前列腺癌患者，按照随机数字法分为对照组和研究组，对照组采用内分泌治疗，研究组采用内分泌治疗联合多西他赛化疗进行治疗。评估两组患者临床疗效、自理能力、血清前列腺特异性抗原监测水平、不良反应发生情况以及患者生活质量。结果：研究组总有效率高于对照组（P<0.05）；治疗后研究组卡氏评分、生存质量评分高于对照组，血清前列腺特异性抗原检测水平低于对照组（P<0.05）；两组性功能障碍、颜面部潮红、乳房发育、皮疹发生情况无统计学差异（P>0.05），研究组中性粒细胞减少、贫血、恶心呕吐、脱发、肝功能不全的发生率高于对照组（P<0.05）。结论：内分泌治疗联合多西他赛化疗应用于前列腺癌患者效果较好，可有效改善患者自理能力、血清前列腺特异性抗原监测水平，提高患者生存质量，但存在较多不良反应。更多还原

【Abstract】 Objective:To explore the effect of endocrine therapy combined with docetaxel chemotherapy on the safety and efficacy of patients with prostate cancer.Methods:120 patients with prostate cancer enrolled in our hospital from January 2020 to June 2023 were divided into control group(n=60)and study group(n=60)according to random number method. The control group was treated with endocrine therapy,and the study group was treated with endocrine therapy combined with docetaxel chemotherapy. The clinical efficacy,self-care ability,monitoring level of serum prostate-specific antigen,occurrence of adverse reactions and quality of life of patients in the two groups were evaluated.Results:The total effective rate of the study group was higher than that of the control group(P<0.05). After treatment,the Cassini score and quality of life score of the study group were higher than those of the control group,and the serum prostate-specific antigen detection level was lower than that of the control group(P<0.05). There were no significant differences in the occurrence of sexual dysfunction,facial flushing,breast development and rash between the two groups(P>0.05). The incidence of neutropenia,anemia,nausea and vomiting,alopecia and liver dysfunction in the study group was higher than that in the control group(P<0.05).Conclusion:Endocrine therapy combined with docetaxel chemotherapy is effective in patients with prostate cancer,which can effectively improve patients’ self-care ability,serum prostate-specific antigen monitoring level,and improve patients’ quality of life,but there are many adverse reactions.更多还原