【摘要】 辅助生殖技术中，控制性促排卵过程中预防内源性黄体生成素（luteinizing hormone,LH）峰的过早出现至关重要。传统的控制性促排卵方案使用促性腺激素释放激素（gonadotropin-releasing hormone,GnRH）类似物（GnRH激动剂或拮抗剂）抑制内源性LH水平，存在成本高、使用不方便等缺点。卵泡期高孕激素状态下促排卵（progestin-primed ovarian stimulation,PPOS）方案利用外源性孕激素对垂体的负反馈作用抑制LH水平，已被证实在各种人群中均可获得较好的临床结局，其子代安全性也得到初步证实。综述PPOS方案的具体机制、不同外源性孕激素类药物的应用、不同人群的应用效果及子代安全性等。更多还原

【Abstract】 In assisted reproductive technology, it is very important to prevent the premature endogenous luteinizing hormone(LH) peak in process of controlled ovarian stimulation. Traditional controlled ovarian stimulation protocols with gonadotropin-releasing hormone(GnRH) analogues(GnRH agonists or antagonists) to inhibit the level of endogenous LH have many disadvantages such as high cost and inconvenient use. Progestinprimed ovarian stimulation(PPOS) protocol has been proved to achieve good clinical outcomes in various populations by the negative feedback effect of exogenous progesterone on pituitary gland to inhibit LH level, and its offspring safety has also been preliminarily confirmed. In this paper, the mechanism of PPOS, application of different exogenous progesterone drugs, application effects of different populations and offspring safety of PPOS were reviewed.更多还原