【摘要】 炎症小体是一种细胞内多蛋白复合体，是人体组织受损后构成局部炎性微环境复杂体系的重要成分。当炎症小体被激活后诱导胱天蛋白酶-1(caspase-1)的活化，介导促炎细胞因子的成熟及分泌，如白细胞介素(IL)-1β和IL-18,并诱导细胞的焦亡，在调节宿主对病原体感染的免疫应答和细胞损伤的组织修复中发挥着重要作用。由NOD样受体蛋白3(NLRP3)、胱天蛋白酶-1前体(pro-caspase-1)和衔接蛋白凋亡相关斑点样蛋白(ASC)组成的NLRP3炎症体是目前研究的最为深入和广泛的炎症小体类型，在炎症调节过程中起着至关重要的作用。当NLRP3炎症小体被激活后，产生和释放炎症介质，参与多种炎症疾病的发生与发展。中医药能够通过抑制NLRP3炎症小体，改善多种疾病的病理状态，发挥防治多种炎症疾病的作用，包括心血管系统疾病、关节炎症、糖尿病等。本文系统性地梳理了NLRP3炎症小体在多种炎症疾病中的作用机制，并总结了中药复方、中药单体及中药提取物作用于NLRP3炎症小体治疗炎症疾病的最新研究报道，以期为多种炎症疾病的发病机制及药物治疗的深入研究提供新思路。更多还原

【Abstract】 Inflammasome is a kind of intracellular polyprotein complex, which is an important component of the complex system of local inflammatory microenvironment after human tissue damage. When the inflammasome is activated, it induces the activation of cysteine aspartate proteinase 1(caspase-1), mediates the maturation and secretion of proinflammatory cytokines, such as interleukin(IL)-1β and IL-18, and induces cell death, which plays an important role in regulating the host immune response to pathogen infection and tissue repair of cell damage. Nod-like receptor protein 3(NLRP3) inflammatory body, which is composed of NLRP3, pro-cysteine aspartic acid specific protease-1(pro-caspase-1) and apoptosis-related spot-like protein(ASC), is the most deeply and widely studied type of inflammatory body, which plays an important role in the regulation of inflammation. When NLRP3 inflammatory bodies are activated, inflammatory mediators are produced and released, which participate in the occurrence and development of a variety of inflammatory diseases. Some studies have shown that traditional Chinese medicine can improve the pathological state of a variety of diseases by inhibiting NLRP3 inflammatory bodies, and play a role in the prevention and treatment of a variety of inflammatory diseases, including cardiovascular diseases, joint inflammation, diabetes and so on. This paper systematically combs the mechanism of NLRP3 inflammatory bodies, and summarizes the latest research reports on the effects of traditional Chinese medicine compound prescription, traditional Chinese medicine monomers and traditional Chinese medicine extracts on NLRP3inflammatory bodies in the treatment of inflammatory diseases, in order to provide new ideas for the further study of the pathogenesis and drug treatment of many inflammatory diseases.更多还原